DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and Gcgr

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_017169752.1	Gene:	Gcgr / 14527	MGIID:	99572	Length:	497	Species:	Mus musculus

Alignment Length:	353	Identity:	103/353 - (29%)
Similarity:	170/353 - (48%)	Gaps:	50/353 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TPAG-TVLSQYCPDFVE-----GFNRKFLAHKTCLENGSWYRHPVSNQTWSNYTNC-VDYEDLEF 190
            |||| |.|....|.|..     |..:..|..|.|..:|.|.|.| ..|.|.|.:.| :|.|::|.
Mouse    80 TPAGLTPLPTPLPTFPAPGTYLGTTKHRLVFKRCGPDGQWVRGP-RGQPWRNASQCQLDDEEIEV 143

  Fly   191 RQFINE-------LYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASL-----ACTCVA 243
            ::.:.:       :|..||:|||.|||::::|.||.:.|.|||..||.:||||.     :...:.
Mouse   144 QKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVID 208

  Fly   244 WILWYRLVVERSETIAEN---PLW--------CIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVVV 297
            |:|..|.    |:.|.::   .:|        |....:::.|.::.||.|:..||::|:.:|.:.
Mouse   209 WLLKTRY----SQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLA 269

  Fly   298 FVKDTIVMRWFIVISWFSP----IPIAIVYGLARHFSSPDNKHCWIT-DSL-YLWIFSVPITLSL 356
            ...:......::.|.|.:|    ||..:|..|.      :|..||.: |:: :.||..:|:.|:|
Mouse   270 TFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLF------ENVQCWTSNDNMGFWWILRIPVFLAL 328

  Fly   357 LASFIFLINVLRVIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPDAGTQ--LDH 419
            |.:|...::::.::|.||.......|....|.| |:|:.|:||.|:...:..:..|...|  |..
Mouse   329 LINFFIFVHIIHLLVAKLRAHQMHYADYKFRLA-RSTLTLIPLLGVHEVVFAFVTDEHAQGTLRS 392

  Fly   420 FYQMLSVVLVSLQGFVVSFLFCFANHDV 447
            ......:.|.|.||.:|:.|:||.|.:|
Mouse   393 TKLFFDLFLSSFQGLLVAVLYCFLNKEV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	20/58 (34%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	64/243 (26%)
Gcgr	XP_017169752.1	7tmB1_GCGR	149..429	CDD:320395	80/283 (28%)
		TM helix 1	154..178	CDD:320395	10/23 (43%)
		TM helix 2	187..208	CDD:320395	6/20 (30%)
		TM helix 3	238..260	CDD:320395	5/21 (24%)
		TM helix 4	279..295	CDD:320395	4/15 (27%)
		TM helix 5	313..336	CDD:320395	7/22 (32%)
		TM helix 6	358..383	CDD:320395	8/25 (32%)
		TM helix 7	392..417	CDD:320395	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810