DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and Adcyap1r1

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_006505451.1	Gene:	Adcyap1r1 / 11517	MGIID:	108449	Length:	523	Species:	Mus musculus

Alignment Length:	460	Identity:	105/460 - (22%)
Similarity:	188/460 - (40%)	Gaps:	123/460 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 EKEELMATVVSATMATNQKENRLF--------CPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFN- 151
            :||:.|.      :...|:.|.|.        ||..:|...||.....|.::...||:....||
Mouse    28 KKEQAMC------LERIQRANDLMGLNESSPGCPGMWDNITCWKPAQIGEMVLVSCPEVFRIFNP 86

  Fly   152 -----------------------RKFLAHKTCLENGSWYRHPVSNQTWSNYTNCVDYEDLE---- 189
                                   ...:..:.|.|:| |      ::.:.:|.:...::|.|
Mouse    87 DQVWMTETIGDSGFADSNSLEITDMGVVGRNCTEDG-W------SEPFPHYFDACGFDDYEPESG 144

  Fly   190 ----FRQFINELYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLACTCVA-----WI 245
                :...:..||..||:.||:.|..:::|...|:.|.|||..||::||.|.....::     ||
Mouse   145 DQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWI 209

  Fly   246 LWYRLVVERSETIAENPLWCIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIV 310
            |:   ..:.|.....:.:.|..:.:..||.::.||||:|.|||:|..:||..|..:.....|:.:
Mouse   210 LY---AEQDSSHCFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTI 271

  Fly   311 ISWFSPIPIAIVYGLARHFSSPDNKHCW-ITDSLYL-WIFSVPITLSLLASFIFLINVLRVIVRK 373
            |.|.:|.....|:.:.|.:.  |:..|| :.||..| |:...|:..|::.:|:..|.::.::|:|
Mouse   272 IGWGTPTVCVTVWAVLRLYF--DDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQK 334

  Fly   374 LH--------------------PQSAQPAPLAI-------------------------------- 386
            |.                    |:.|:..||.:
Mouse   335 LQSPDMGGNESSIYLTNLRLRVPKKAREDPLPVPSDQHSPPFLCVQKCYCKPQRAQQHSCKMSEL 399

  Fly   387 ----RKAVRATIILVPLFGLQHFLLPYRPDAGTQLDHFYQMLSVVLVSLQGFVVSFLFCFANHDV 447
                .:..|:|::|:||||:.:.:..:.|:..::.:..  :..:.|.|.|||||:.|:||.|.:|
Mouse   400 STITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERL--VFELGLGSFQGFVVAVLYCFLNGEV 462

  Fly   448 TFAIR 452
            ...|:
Mouse   463 QAEIK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	16/98 (16%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	66/282 (23%)
Adcyap1r1	XP_006505451.1	HRM	52..137	CDD:367186	15/91 (16%)
		7tmB1_PACAP-R1	150..472	CDD:320653	82/325 (25%)
		TM helix 1	153..177	CDD:320653	8/23 (35%)
		TM helix 2	186..207	CDD:320653	5/20 (25%)
		TM helix 3	227..249	CDD:320653	8/21 (38%)
		TM helix 4	268..284	CDD:320653	4/15 (27%)
		TM helix 5	302..325	CDD:320653	6/22 (27%)
		TM helix 6	404..429	CDD:320653	7/24 (29%)
		TM helix 7	434..459	CDD:320653	10/26 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810