DRSC/TRiP Functional Genomics Resources

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Protein Alignment hec and CALCRL

DIOPT Version :9

Sequence 1:NP_001285174.1 Gene:hec / 32246 FlyBaseID:FBgn0030437 Length:486 Species:Drosophila melanogaster
Sequence 2:XP_005246289.2 Gene:CALCRL / 10203 HGNCID:16709 Length:472 Species:Homo sapiens


Alignment Length:349 Identity:133/349 - (38%)
Similarity:200/349 - (57%) Gaps:9/349 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 QKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAHKTCLENGSWYRHPVSNQTWS 177
            |:...::|...:||:|||....|||...|.|||:.:.|:......|.|.::|:|:|||.||:||:
Human    69 QQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWT 133

  Fly   178 NYTNCVDYEDLEFRQFINELY--VKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLACT 240
            |||.|......:.:..:|..|  :.|:.||:.:||||:.||..||||.|.||.:|.:||.|..|.
Human   134 NYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCN 198

  Fly   241 CVAWILWYRLVVERSETIAENPLWCIGLHLVVHYFMLVNYFWMFCEGLHLH-LVLVVVFVKDTIV 304
            .|..|:....|......:|.||:.|.....:..|.|..|||||.|||::|| |::|.||.:...:
Human   199 SVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHL 263

  Fly   305 MRWFIVISWFSPIPIAIVYGLARHFSSPDNKHCWI-TDSLYLWIFSVPITLSLLASFIFLINVLR 368
            | |:..:.|..|:..|.::.:||.....||  ||| :|:..|:|...||..:||.:..||:|::|
Human   264 M-WYYFLGWGFPLIPACIHAIARSLYYNDN--CWISSDTHLLYIIHGPICAALLVNLFFLLNIVR 325

  Fly   369 VIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPDAGTQLDHFYQMLSVVLVSLQG 433
            |::.||.......:.|.: ||||||:|||||.|::..|:|:||: |...:..|..:..:|:..||
Human   326 VLITKLKVTHQAESNLYM-KAVRATLILVPLLGIEFVLIPWRPE-GKIAEEVYDYIMHILMHFQG 388

  Fly   434 FVVSFLFCFANHDVTFAIRTLLNK 457
            .:||.:|||.|.:|...:|...|:
Human   389 LLVSTIFCFFNGEVQAILRRNWNQ 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hecNP_001285174.1 HRM 118..185 CDD:280888 29/66 (44%)
7tm_4 216..436 CDD:304433 84/221 (38%)
CALCRLXP_005246289.2 HRM 73..141 CDD:397086 29/67 (43%)
7tmB1_calcitonin_R 149..422 CDD:341343 103/269 (38%)
TM helix 1 152..176 CDD:341343 10/23 (43%)
TM helix 2 185..206 CDD:341343 8/20 (40%)
TM helix 3 224..246 CDD:341343 9/21 (43%)
TM helix 4 265..281 CDD:341343 4/15 (27%)
TM helix 5 298..321 CDD:341343 8/22 (36%)
TM helix 6 346..368 CDD:341343 13/21 (62%)
TM helix 7 374..399 CDD:341343 9/24 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 180 1.000 Domainoid score I3511
eggNOG 1 0.900 - - E1_KOG4564
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46801
OrthoDB 1 1.010 - - D1005634at2759
OrthoFinder 1 1.000 - - FOG0001436
OrthoInspector 1 1.000 - - mtm8532
orthoMCL 1 0.900 - - OOG6_105420
Panther 1 1.100 - - O PTHR45620
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X66
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.790

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