DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hec and pth1r

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_002939411.2	Gene:	pth1r / 100492020	XenbaseID:	XB-GENE-957445	Length:	540	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	120/404 - (29%)
Similarity:	209/404 - (51%)	Gaps:	46/404 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NVDEELAEKEELM------ATVVSATMATNQKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFV 147
            :.|:.:.::|:::      |.......::..|.:...|...:||.:|||....|..:|..||:::
Frog    28 DADDVITKEEQILLLWNAKALCEKLLSSSASKAHDGLCLPEWDGVVCWPEGLPGNTVSISCPEYI 92

  Fly   148 EGFNRKFLAHKTCLENGSWYRHPVSNQTWSNYTNCVDY--EDLEFRQFINELYV---KGYALSLL 207
            :.||.|..|::.|..||||...|.:|:||:|||.|..|  .:.:.|:..:.||:   .||::||.
Frog    93 QDFNHKGHAYRRCDMNGSWELVPGNNRTWANYTECAKYLFNETKEREVFDRLYLIYTVGYSISLG 157

  Fly   208 ALLISIIIFLGFKSLRCTRIRIHVHLFASLACTCVA-----WILWYRLVVERSETIAENPL---- 263
            :|.::::|...|:.|.|||..||:|||.|......:     .:|:....:|.:|.|:|..|
Frog   158 SLTVAVLILGYFRRLHCTRNYIHMHLFISFMLRAGSIFVKDAVLYSGSALEETELISEEDLKFIT 222

  Fly   264 --------WCIGLHLVVH---YFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPI 317
                    ..:|..:||.   ||:..||:|:..|||:||.::.:.|:.|...:..|.:..|..|.
Frog   223 EIPPADKMQFVGCKVVVTFFLYFLATNYYWILVEGLYLHSLIFMAFISDKKYLWGFTLFGWGVPA 287

  Fly   318 PIAIVYGLARHFSSPDNKHCWITDSLYL-WIFSVPITLSLLASFIFLINVLRVIVRKLHPQSAQP 381
            ...:::  ||..::..:..||...:.|| ||..|||..:::.:|...||::||:..||...:|..
Frog   288 IFVLIW--ARERATVADTGCWDLSAGYLKWIVQVPILAAIMVNFGLFINIVRVLATKLRETNAGR 350

  Fly   382 APL--AIRKAVRATIILVPLFGLQHFLL----PYRPDAGT--QLDHFYQMLSVVLVSLQGFVVSF 438
            ...  ..||.:::|::|:||||: |:::    ||...:|.  |:...|::|   ..|.|||.|:.
Frog   351 CDTRQQYRKLLKSTLVLMPLFGV-HYIVFMAFPYTEVSGILWQVQMHYELL---FNSFQGFFVAI 411

  Fly   439 LFCFANHDVTFAIR 452
            ::||.|.:|...|:
Frog   412 IYCFCNGEVQAEIK 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	27/66 (41%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	73/248 (29%)
pth1r	XP_002939411.2	HRM	65..127	CDD:367186	26/61 (43%)
		7tmB1_PTH1R	141..430	CDD:320650	87/291 (30%)
		TM helix 1	143..168	CDD:320650	8/24 (33%)
		TM helix 2	177..199	CDD:320650	6/21 (29%)
		TM helix 3	236..263	CDD:320650	12/26 (46%)
		TM helix 4	275..295	CDD:320650	3/21 (14%)
		TM helix 5	310..339	CDD:320650	11/28 (39%)
		TM helix 6	356..383	CDD:320650	9/27 (33%)
		TM helix 7	392..417	CDD:320650	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000