DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hec and gcgr

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_004916426.1	Gene:	gcgr / 100487356	XenbaseID:	XB-GENE-5918476	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	353	Identity:	93/353 - (26%)
Similarity:	170/353 - (48%)	Gaps:	34/353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKF---LAHKTCLENGSWYRHPVSNQTWSNY 179
            |.|...||.|.|||.....|.:|..||.|:. ::.|.   |.:|.|..:|.|.....  |...|.
Frog    52 LVCNRTFDRYCCWPDALPNTTVSVPCPWFLP-WHLKVQHGLVYKHCEPDGQWAERDA--QECEND 113

  Fly   180 TNCVDYEDLEFRQFIN--ELYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLACTCV 242
            ...:  ||..|:.:.|  .:|..||::||..|:::..|.:||..|.|.|..||::||||.....|
Frog   114 DKQI--EDKYFKIYDNFKIMYTVGYSVSLGTLILAFAILVGFSKLHCMRNYIHINLFASFILRAV 176

  Fly   243 AWILWYRLVVER---SETIAENPLW--------CIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVV 296
            :.::...::..|   :|...:..||        |....:::.|.::.||:|:..||::|:.:||:
Frog   177 SVLVLDTMLKTRYNENEKFEDTHLWLSSEALVGCRVAAVLMQYGIIANYYWLMVEGIYLYNLLVL 241

  Fly   297 VFVKDTIVMRWFIVISWFSPIPIAIVYGLARHFSSPDNKHCWITDSL--YLWIFSVPITLSLLAS 359
            ....:......::.|.|.:|....|.:...|:  :.:|..||.|::.  :.||....:.|:::.:
Frog   242 AVFSERSYFALYLCIGWGAPALFIIPWVAVRY--TYENTLCWSTNNNMGFWWIIRSSVLLAIVIN 304

  Fly   360 FIFLINVLRVIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPDA---GT--QLDH 419
            |:..:.:::::|.|:.....:......|.| ::|:.|:||.|:......:.|:.   ||  .:..
Frog   305 FVIFVRIIQILVSKMRAHQMRYTDYKFRLA-KSTLTLIPLLGIHEVAFAFLPEETVHGTLRLVKL 368

  Fly   420 FYQMLSVVLVSLQGFVVSFLFCFANHDV 447
            |:.:.   :.|.||.:|:.|:||.|.:|
Frog   369 FFDLF---ISSFQGMLVAVLYCFVNKEV 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	21/69 (30%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	55/237 (23%)
gcgr	XP_004916426.1	HRM	51..113	CDD:367186	20/63 (32%)
		7tmB1_GCGR	123..403	CDD:320395	69/277 (25%)
		TM helix 1	127..152	CDD:320395	8/24 (33%)
		TM helix 2	161..183	CDD:320395	7/21 (33%)
		TM helix 3	211..238	CDD:320395	7/26 (27%)
		TM helix 4	250..270	CDD:320395	4/19 (21%)
		TM helix 5	286..315	CDD:320395	4/28 (14%)
		TM helix 6	331..356	CDD:320395	7/25 (28%)
		TM helix 7	365..390	CDD:320395	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000