DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fne and elavl2

DIOPT Version :9

Sequence 1:	NP_001096965.1	Gene:	fne / 32245	FlyBaseID:	FBgn0086675	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_012819022.1	Gene:	elavl2 / 594913	XenbaseID:	XB-GENE-491749	Length:	390	Species:	Xenopus tropicalis

Alignment Length:	364	Identity:	220/364 - (60%)
Similarity:	265/364 - (72%)	Gaps:	34/364 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NAMDIVKNGSANGSVDGSN-DESRTNLIVNYLPQTMTQEEMRSLFSSIGELESCKLVRDKVSGNL 66
            |..:.:.|.|:  .|:.|| ::|:||||||||||.|||||::|||.||||:|||||||||::
Frog    45 NCPNTINNCSS--PVESSNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKIT--- 104

  Fly    67 VLPASLTALNPALQQGQSLGYGFVNYVRAEDAEKAVNTLNGLRLQNKVIKVSYARPSSESIKGAN 131
                          :|||||||||||:..:|||||:|||||||||.|.||||||||||.||:.||
Frog   105 --------------EGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDAN 155

  Fly   132 LYVSGLPKNLSQPDLEGMFASFGKIITSRILCDNISGLSKGVGFIRFDQRNEAERAIQELNGKTP 196
            ||||||||.::|.:||.:|:.:|:|||||||.|.::|:|:||||||||:|.|||.||:.|||:.|
Frog   156 LYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKP 220

  Fly   197 KGYAEPITVKFANNPSNSAKAQI-----APPLTAYLTPQAAAATR-RLAGALPSA-GRI--RYSP 252
            .|..||||||||||||......|     ..|...|..|.|..|.| ||...|..| |.|  |:||
Frog   221 PGATEPITVKFANNPSQKVNHTILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGGIKSRFSP 285

  Fly   253 LAGD---LLANSILPGNAMTGSGWCIFVYNLAPETEENVLWQLFGPFGAVQSVKVIRDLQTSKCK 314
            :..|   .||....||:|  |:|||||||||||:.:|::|||:|||||||.:||||||..|:|||
Frog   286 MTIDGMTSLAGINFPGHA--GTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCK 348

  Fly   315 GFGFVTMTNYDEAVVAIQSLNGYTLGNRVLQVSFKTNKT 353
            |||||||||||||.:||.|||||.||:|||||||||:||
Frog   349 GFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fne	NP_001096965.1	ELAV_HUD_SF	23..354	CDD:273741	214/343 (62%)
elavl2	XP_012819022.1	ELAV_HUD_SF	64..389	CDD:273741	214/343 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20930
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1795
OMA	1	1.010	-	-		QHG55893
OrthoDB	1	1.010	-	-		D425303at33208
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	1	1.000	-	-		mtm9409
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3804
SonicParanoid	1	1.000	-	-		X326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110