DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fne and elavl4

DIOPT Version :9

Sequence 1:	NP_001096965.1	Gene:	fne / 32245	FlyBaseID:	FBgn0086675	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001231529.1	Gene:	elavl4 / 30737	ZFINID:	ZDB-GENE-990415-246	Length:	411	Species:	Danio rerio

Alignment Length:	389	Identity:	222/389 - (57%)
Similarity:	267/389 - (68%)	Gaps:	63/389 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNAMDIVKNG----SANG------------SVDGSNDESRTNLIVNYLPQTMTQEEMRSLFSSI 49
            ::|....|.||    :|||            ...||||:|:||||||||||.|||||.||||.||
Zfish    47 ISNMEPQVTNGPNSATANGPSSNSRSCPSPMQTGGSNDDSKTNLIVNYLPQNMTQEEFRSLFGSI 111

  Fly    50 GELESCKLVRDKVSGNLVLPASLTALNPALQQGQSLGYGFVNYVRAEDAEKAVNTLNGLRLQNKV 114
            ||:|||||||||::                  |||||||||||:..:|||||:|||||||||.|.
Zfish   112 GEIESCKLVRDKIT------------------GQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKT 158

  Fly   115 IKVSYARPSSESIKGANLYVSGLPKNLSQPDLEGMFASFGKIITSRILCDNISGL---SKGVGFI 176
            ||||||||||.||:.||||||||||.::|.:||.:|:.:|:|||||||.|.::|.   |:|||||
Zfish   159 IKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGPTGGSRGVGFI 223

  Fly   177 RFDQRNEAERAIQELNGKTPKGYAEPITVKFANNPSNSAKAQIAPPLTAYLTPQAAAATRRLAGA 241
            |||:|.|||.||:.|||:.|.|.|||||||||||||......:...|  |.:|     .||..|.
Zfish   224 RFDKRIEAEEAIKGLNGQKPSGAAEPITVKFANNPSQKTSQALLSQL--YQSP-----NRRYPGP 281

  Fly   242 L--------------PSAGRIRYSPLAGDLLANSI---LPGNAMTGSGWCIFVYNLAPETEENVL 289
            |              .:.|..|:||:..|.:.:.:   :||:  ||:|||||||||:|:::|:||
Zfish   282 LHHQAQRFRLDNLLNMAYGVKRFSPITIDSMTSLVGMNIPGH--TGTGWCIFVYNLSPDSDESVL 344

  Fly   290 WQLFGPFGAVQSVKVIRDLQTSKCKGFGFVTMTNYDEAVVAIQSLNGYTLGNRVLQVSFKTNKT 353
            ||||||||||.:||||||..|:||||||||||||||||.:||.|||||.||:||||||||||||
Zfish   345 WQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKT 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fne	NP_001096965.1	ELAV_HUD_SF	23..354	CDD:273741	211/351 (60%)
elavl4	NP_001231529.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..89		11/38 (29%)
elavl4	NP_001231529.1	ELAV_HUD_SF	85..410	CDD:273741	211/351 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5514
eggNOG	1	0.900	-	-		E1_KOG0145
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1806
OMA	1	1.010	-	-		QHG55893
OrthoDB	1	1.010	-	-		D425303at33208
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	1	1.000	-	-		mtm6531
orthoMCL	1	0.900	-	-		OOG6_103306
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3804
SonicParanoid	1	1.000	-	-		X326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870