Protein Alignment HOXC8 and Dbx

DIOPT Version :10

• Sequence 1: NP_073149.1
• Gene: HOXC8 / 3224
• HGNCID: 5129
• Length: 242
• Species: Homo sapiens
• Sequence 2: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 293
• Identity: 68/293 - (23%)
• Similarity: 98/293 - (33%)
• Gaps: 101/293 - (34%)

Human     3 SYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPG----------GSAPG---FQHASH 54
            ::|.:|.|..::.     |.:...:..|.|.:.|     ||          .|:||   ....::
  Fly   239 AHFPHPAFLTHQL-----PPHQHHQQQQHVQQQH-----PGNSCQPQTASSSSSPGSTISDSDNN 293

Human    55 HVQDFFHHGTSGISNSGYQQNPCSLSC-----HGDASKFYGYEALPRQSLYGAQQEASVVQYPDC 114
            |.....:...||..|||....|..|:.     ...||:....:...:|.|.||
  Fly   294 HGASTANGNGSGTGNSGQDARPHELANSNPDEDSSASRRLTQDKQQQQQLLGA------------ 346

Human   115 KSSANTNSSEGQGH-------------------------------LNQNSSPSLM---------- 138
               ..|....|.||                               ||.....||:
  Fly   347 ---GGTGGGGGGGHGHGHPTPPPPPPPPVIAKPMPSRPTPFLPHTLNHPHLHSLLAHCRNPYMSV 408

Human   139 ------------FPWMRPHAPGRRSG---RQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGL 188
                        |||........|.|   |..:|..|...|||.|....|:::..|.:::..|||
  Fly   409 GAQVFPLPPGQGFPWAHSTRGKPRRGMMRRAVFSDSQRKGLEKRFQQQKYISKPDRKKLAERLGL 473

Human   189 TERQVKIWFQNRRMKWKKENNKDKLP--GARDE 219
            .:.|||||||||||||:....::.|.  |:||:
  Fly   474 KDSQVKIWFQNRRMKWRNSKERELLASGGSRDQ 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXC8	NP_073149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..154		13/95 (14%)
		Antp-type hexapeptide	138..143		3/26 (12%)
		Homeodomain	150..206	CDD:459649	27/58 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..242		4/16 (25%)
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	25/53 (47%)