DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Coq8 and coq8b

DIOPT Version :9

Sequence 1:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_021322006.1	Gene:	coq8b / 799071	ZFINID:	ZDB-GENE-060503-803	Length:	656	Species:	Danio rerio

Alignment Length:	555	Identity:	258/555 - (46%)
Similarity:	364/555 - (65%)	Gaps:	36/555 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 DISSIT-----LQEFEEILSRRNKDRSVSLRTPATKSNQTMPKKETSTNP-----------GIIT 179
            |::|.|     ::::||:........||:...|...|::. .:.|||..|           |...
Zfish    92 DMTSKTDEFAGIEKWEEMDLDEAAKWSVASEMPPDFSSKD-GRGETSETPVGAATGTIKGAGWPA 155

  Fly   180 QDTEYVN-----NVLRFVAGAKVEE-QPPDAQPKKKSDQ----PAIEVPELSKVAKQRKVPSSRI 234
            |:|.:::     :..|||..:.|.. .|.|.|..:::.|    |..:  :|::.||:||||::||
Zfish   156 QNTRFLHVSASQHHFRFVHDSIVARLSPEDIQRAREAKQNIARPVRQ--KLNERAKERKVPATRI 218

  Fly   235 GRMASFGGLFAGLGLGTLNELTKGALGLGGSTS-----MREALLSPANAERIVDTLCKVRGAALK 294
            .|:|:||||..|||:|.:.|:.|.:  .||..|     :...|||.|||||||:|||||||||||
Zfish   219 SRLANFGGLAVGLGIGAIAEVAKQS--FGGKRSEVGALLDSPLLSEANAERIVNTLCKVRGAALK 281

  Fly   295 IGQILSIQDSSVVSPQLAKAFERVRQAADYMPDWQVERVMNTQLGADWRQRLKSFEDKPFAAASI 359
            |||:|||||:|.::|||.|.||||||:||:||.||:.:|:..:||:.||::|.|.|:||||||||
Zfish   282 IGQMLSIQDNSFINPQLQKIFERVRQSADFMPAWQMHKVLEEELGSGWREKLSSIEEKPFAAASI 346

  Fly   360 GQVHRATLSDGMDVAIKIQYPGVAQSIESDIDNLVGMLKVWDVFPQGFFIDNVVRVAKRELQWEV 424
            ||||...|..|.::|:||||||||:||.|||:||:.:||:..|.|.|.|.|:.:.|.:|||.||.
Zfish   347 GQVHHGVLPGGKEIAMKIQYPGVAESIHSDINNLMSVLKMSVVLPDGLFADSSLEVLQRELAWEC 411

  Fly   425 DYDREAEYTEKFREMIAPYPEYYVPRVVRDLTTSSVLTTELVPGVPLDKCFDLSYEHRRHIAASV 489
            ||:|||:..::||.::...|.:.||.|..:|:...|:|.|||.|||||:|.||..|.|..|..::
Zfish   412 DYEREAKCAKRFRNLLKGDPVFVVPEVFDELSARRVITMELVNGVPLDRCVDLDQETRNEICFNI 476

  Fly   490 LKLCLRELFEIECMQTDPNWSNFLYDAPSRRLMLIDFGSTRFYRHEFIRNYRRVIMSAAENNRQG 554
            |:||||||||...||||||||||.|::...::.|:|||:.|.|...|..:|..|:.:|:..:|..
Zfish   477 LQLCLRELFEFRFMQTDPNWSNFFYNSEQNKIFLLDFGACRDYPELFTDHYIEVVHAASVGDRAT 541

  Fly   555 VLEMSREMGFLTGYETKQMEQAHVDAVMILGEIFRYDGDFDFGRQNTTERLAALVPTMVAHRLCP 619
            ||:.|:::.||||:|.|..|.|||:|||||||.|.....||||.|:||:|:.:|:|.|:.|||.|
Zfish   542 VLKKSKDLKFLTGFEAKAFEDAHVEAVMILGEAFASAEAFDFGTQSTTQRIQSLIPVMLRHRLTP 606

  Fly   620 PPEEIYSIHRKLSGIFLLCARLNVRMNCVPFYKDI 654
            ||||.||:|||::|.||:|::|..|.:|...:.|:
Zfish   607 PPEESYSLHRKMAGSFLICSKLKARFSCRNMFLDV 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq8	NP_572836.1	AarF	262..641	CDD:223733	208/383 (54%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	126/249 (51%)
coq8b	XP_021322006.1	ABC1_ADCK3	300..550	CDD:270872	126/249 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584073
Domainoid	1	1.000	227	1.000	Domainoid score	I2435
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1426
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm25139
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940