DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Coq8 and Coq8b

DIOPT Version :9

Sequence 1:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_598531.2	Gene:	Coq8b / 76889	MGIID:	1924139	Length:	533	Species:	Mus musculus

Alignment Length:	447	Identity:	237/447 - (53%)
Similarity:	315/447 - (70%)	Gaps:	16/447 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 PELSKVAKQRKVPSSRIGRMASFGGLFAGLGLGTLNELTK-----------GALGLGGSTSMREA 271
            |:||..:::||||:|||.|:||||||..|||||.|.|:||           |..|||.|     .
Mouse    74 PQLSDRSRERKVPASRISRLASFGGLAVGLGLGALAEVTKKSLPGGSLQHEGVSGLGSS-----P 133

  Fly   272 LLSPANAERIVDTLCKVRGAALKIGQILSIQDSSVVSPQLAKAFERVRQAADYMPDWQVERVMNT 336
            .||.|||||||.|||.||||||||||:|||||:|.:||||.:.||||||:||:||.||:.||:..
Mouse   134 FLSEANAERIVQTLCTVRGAALKIGQMLSIQDNSFISPQLQRIFERVRQSADFMPRWQMMRVLEE 198

  Fly   337 QLGADWRQRLKSFEDKPFAAASIGQVHRATLSDGMDVAIKIQYPGVAQSIESDIDNLVGMLKVWD 401
            :||.||:.::.|.|:.|||||||||||:..|.||.:||:|||||||||||:||::||:.:||:..
Mouse   199 ELGKDWQDKVASLEEVPFAAASIGQVHQGLLKDGTEVAVKIQYPGVAQSIQSDVENLLALLKMSV 263

  Fly   402 VFPQGFFIDNVVRVAKRELQWEVDYDREAEYTEKFREMIAPYPEYYVPRVVRDLTTSSVLTTELV 466
            ..|:|.|.:..::..::||.||.||.|||...:.||:::|..|.:.||.||::|.|:.||..||.
Mouse   264 GLPEGLFAEQSLQTLQQELAWECDYCREAACAQTFRKLLADDPFFRVPAVVQELCTTRVLGMELA 328

  Fly   467 PGVPLDKCFDLSYEHRRHIAASVLKLCLRELFEIECMQTDPNWSNFLYDAPSRRLMLIDFGSTRF 531
            .|:|||:|..||.:.|..|...:|:||||||||...|||||||:||||||.|.::.|:|||::|.
Mouse   329 GGIPLDQCQGLSQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASRA 393

  Fly   532 YRHEFIRNYRRVIMSAAENNRQGVLEMSREMGFLTGYETKQMEQAHVDAVMILGEIFRYDGDFDF 596
            :..||..:|..|:.:||:.:|..||:.|:::.||||:|||....|||:|||||||.|...|.:||
Mouse   394 FGTEFTDHYIEVVKAAADGDRDRVLQKSQDLKFLTGFETKAFSDAHVEAVMILGEPFAASGPYDF 458

  Fly   597 GRQNTTERLAALVPTMVAHRLCPPPEEIYSIHRKLSGIFLLCARLNVRMNCVPFYKD 653
            |...|..|:..|:|.::.|||.|||||.|::||||:|.||.||||:..:.|...::|
Mouse   459 GAGETARRIQGLIPVLLRHRLRPPPEETYALHRKLAGAFLACARLHAHIACRDLFQD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq8	NP_572836.1	AarF	262..641	CDD:223733	205/378 (54%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	126/249 (51%)
Coq8b	NP_598531.2	KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	156..159		2/2 (100%)
		ABC1_ADCK3	176..425	CDD:270872	126/248 (51%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	217..220		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839968
Domainoid	1	1.000	220	1.000	Domainoid score	I2607
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86731
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1463
Isobase	1	0.950	-	0	Normalized mean entropy	S962
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm42362
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750