DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Coq8 and COQ8A

DIOPT Version :9

Sequence 1:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_064632.2	Gene:	COQ8A / 56997	HGNCID:	16812	Length:	647	Species:	Homo sapiens

Alignment Length:	471	Identity:	238/471 - (50%)
Similarity:	321/471 - (68%)	Gaps:	14/471 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 VAGAKVEE----QPPDAQPKKKSDQPAIEVPELSKVAKQRKVPSSRIGRMASFGGLFAGLGLGTL 252
            |.|...|:    :...|:|:.|..:..     ||:.|::||||.:||||:|:||||..|||.|.|
Human   170 VGGLTAEDIEKARQAKARPENKQHKQT-----LSEHARERKVPVTRIGRLANFGGLAVGLGFGAL 229

  Fly   253 NELTKGALGLGGSTSMREAL-----LSPANAERIVDTLCKVRGAALKIGQILSIQDSSVVSPQLA 312
            .|:.|.:|.....:..:..|     ||.|||||||.|||||||||||:||:|||||.:.::|.||
Human   230 AEVAKKSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLA 294

  Fly   313 KAFERVRQAADYMPDWQVERVMNTQLGADWRQRLKSFEDKPFAAASIGQVHRATLSDGMDVAIKI 377
            |.||||||:||:||..|:.:.:|..||.:||.:|:.||::|||||||||||.|.:..|.:||:||
Human   295 KIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKI 359

  Fly   378 QYPGVAQSIESDIDNLVGMLKVWDVFPQGFFIDNVVRVAKRELQWEVDYDREAEYTEKFREMIAP 442
            |||||||||.||::||:.:|.:.::.|:|.|.::::.|.:|||..|.||.|||....|||:::..
Human   360 QYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKG 424

  Fly   443 YPEYYVPRVVRDLTTSSVLTTELVPGVPLDKCFDLSYEHRRHIAASVLKLCLRELFEIECMQTDP 507
            :|.:|||.:|.:|.:..|||||||.|.|||:...||.|.|..|..::|.||||||||...|||||
Human   425 HPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDP 489

  Fly   508 NWSNFLYDAPSRRLMLIDFGSTRFYRHEFIRNYRRVIMSAAENNRQGVLEMSREMGFLTGYETKQ 572
            |||||.||....::.|:|||:||.|...|...|.::|.:||:.:|:.|...|.||.||||||.|.
Human   490 NWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKV 554

  Fly   573 MEQAHVDAVMILGEIFRYDGDFDFGRQNTTERLAALVPTMVAHRLCPPPEEIYSIHRKLSGIFLL 637
            ||.||:||::||||.|..|..||||.|:|||::..|:|.|:.|||.|||||.||:|||:.|.||:
Human   555 MEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLI 619

  Fly   638 CARLNVRMNCVPFYKD 653
            |::|..|..|...:::
Human   620 CSKLKARFPCKAMFEE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq8	NP_572836.1	AarF	262..641	CDD:223733	205/383 (54%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	126/249 (51%)
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		6/25 (24%)
		KxGQ motif. /evidence=ECO:0000269\|PubMed:25498144	276..279		1/2 (50%)
		ABC1_ADCK3	295..545	CDD:270872	126/249 (51%)
		AAAS motif. /evidence=ECO:0000269\|PubMed:25498144	337..340		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2677
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1533
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm40296
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	O	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.010