DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Coq8 and coq8ab

DIOPT Version :9

Sequence 1:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_002665174.2	Gene:	coq8ab / 327332	ZFINID:	ZDB-GENE-030131-5543	Length:	567	Species:	Danio rerio

Alignment Length:	544	Identity:	246/544 - (45%)
Similarity:	345/544 - (63%)	Gaps:	51/544 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 RNKDRSVSLRTPATK---------------------SNQTMPKKETSTNP---------GIITQD 181
            |.:.:.||..||..:                     |:|.:.:.....:|         |...||
Zfish    23 RGRQKQVSFLTPQLRGQVSCGHQTALSFSGVMGVFGSDQHLSRLFGKIHPDQQHIYSQIGFFHQD 87

  Fly   182 TEYVNNVLR-FVAGAKVEEQPPDAQPKKKSDQPAIEVPELSKVAKQRKVPSSRIGRMASFGGLFA 245
            ..|.:.:.: .|.|.|.:        .:|.:|      :||:.|::||:|.:||||:.:||||..
Zfish    88 HRYYSALKKEGVKGVKAD--------SRKHNQ------KLSESARERKMPVTRIGRLVNFGGLAV 138

  Fly   246 GLGLGTLNELTKGALGLGGSTSMREALL------SPANAERIVDTLCKVRGAALKIGQILSIQDS 304
            |||:|.:.|:.|.:.....::..::|:|      |.|||||||.|||||||||||:||:|||||.
Zfish   139 GLGIGAIAEVAKKSFASRDNSGQKKAILDSNPFISEANAERIVRTLCKVRGAALKLGQMLSIQDD 203

  Fly   305 SVVSPQLAKAFERVRQAADYMPDWQVERVMNTQLGADWRQRLKSFEDKPFAAASIGQVHRATLSD 369
            :.::|||||.||||||:||:||..|..:::.:.||.:|:..|:.||::|||||||||||.|.:.|
Zfish   204 AFINPQLAKIFERVRQSADFMPAKQTMKMVVSDLGPNWQDHLEYFEERPFAAASIGQVHLARMKD 268

  Fly   370 GMDVAIKIQYPGVAQSIESDIDNLVGMLKVWDVFPQGFFIDNVVRVAKRELQWEVDYDREAEYTE 434
            |.:||:||||||||:||.|||:||:.:|.:....|:|.|.::::.|..|||..|.||.|||:..:
Zfish   269 GREVAMKIQYPGVAKSISSDINNLLTLLSISHALPEGLFPEHLIEVMSRELALECDYIREAKCAK 333

  Fly   435 KFREMIAPYPEYYVPRVVRDLTTSSVLTTELVPGVPLDKCFDLSYEHRRHIAASVLKLCLRELFE 499
            ||::::..:|.:.||.||.:|::..|||||||.|.||||..||..|.:..|...:|.||||||||
Zfish   334 KFQQLLKGHPFFSVPNVVDELSSKHVLTTELVSGFPLDKAEDLPQELKNEICEQILILCLRELFE 398

  Fly   500 IECMQTDPNWSNFLYDAPSRRLMLIDFGSTRFYRHEFIRNYRRVIMSAAENNRQGVLEMSREMGF 564
            ...||||||||||.:|..:.::.|:|||:||.:...|...|..:|.:||:.||:|||:.|.:|.|
Zfish   399 FRYMQTDPNWSNFFFDPQTHKVALLDFGATRGFDASFTDTYIEIIKAAADRNREGVLQRSIDMKF 463

  Fly   565 LTGYETKQMEQAHVDAVMILGEIFRYDGDFDFGRQNTTERLAALVPTMVAHRLCPPPEEIYSIHR 629
            |||||:|.|..|||||||||||.|..|..||||.|:||||:..|:|.|:..||.|||||.||:||
Zfish   464 LTGYESKSMVNAHVDAVMILGEAFSSDEPFDFGSQSTTERIHRLIPVMLKERLTPPPEETYSLHR 528

  Fly   630 KLSGIFLLCARLNVRMNCVPFYKD 653
            |:.|.||:|:||..::.|...:::
Zfish   529 KMGGSFLICSRLKAQICCKNMFQE 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq8	NP_572836.1	AarF	262..641	CDD:223733	206/384 (54%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	124/249 (50%)
coq8ab	XP_002665174.2	ABC1_ADCK3	212..462	CDD:270872	124/249 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2435
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1426
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm25139
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	O	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.970