DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Coq8 and abc1

DIOPT Version :9

Sequence 1:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_596237.1	Gene:	abc1 / 2540411	PomBaseID:	SPBC2D10.18	Length:	610	Species:	Schizosaccharomyces pombe

Alignment Length:	627	Identity:	221/627 - (35%)
Similarity:	333/627 - (53%)	Gaps:	88/627 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HTQQL--VRSSSQNPTEELKKLQQTVKETGERGYVVAKGICSLLETKIKMSREESAISEPAQVSS 111
            |.|.|  .|:.......::|:|..:.|:|..          :||...:.:.::.|.:....:.||
pombe    53 HVQLLEKYRNGKVKHASQIKELGLSSKDTKR----------TLLGNSLDVQKDASGVKHLQEQSS 107

  Fly   112 IRKSTPTAQ----------NPASWDAANLDISSITLQEFEEILSRRNKDRSVSLRTPATKSNQTM 166
            .....|.:|          :||...|.:..|..:|...                  |||.:|
pombe   108 KEIKNPISQPILPNKKDEISPAKPSAIDSSIKDVTKSH------------------PATNAN--- 151

  Fly   167 PKKETSTNPGIITQDTEYVNNVLRFVAGAKVEEQPPDAQPKKKSDQPAIEVPELSKVAKQRKVPS 231
                       .|.|.|           :.:||   ....:.||  |.|        ....||||
pombe   152 -----------FTADFE-----------SSIEE---SYSTENKS--PVI--------LSSSKVPS 181

  Fly   232 SRIGRMASFGGLFAGLGLGTLNELTKGALGLGGSTSMREALLSPANAERIVDTLCKVRGAALKIG 296
            |:..|:..:|||...|.:|.:.|..|...|:  |......||:..|.|.:|:.|.::||||||:|
pombe   182 SQWSRLWHYGGLATSLSVGAIGEKMKRMWGI--SKDDGALLLNERNVEILVNKLTQMRGAALKMG 244

  Fly   297 QILSIQDSSVVSPQLAKAFERVRQAADYMPDWQVERVMNTQLGADWRQRLKSFEDKPFAAASIGQ 361
            |:||.|||.::.|::::..||||..|..||:.|:|:||...||.:|......|:.||.|||||||
pombe   245 QMLSFQDSKLIDPRVSQILERVRDGAHSMPEKQLEQVMVKNLGKNWMTHYSEFDRKPMAAASIGQ 309

  Fly   362 VHRATL-SDGMDVAIKIQYPGVAQSIESDIDNLVGMLKVWDVFPQGFFIDNVVRVAKRELQWEVD 425
            ||||.| |:.|:|.:|:|||||..||:||::||..:||...:.|:|.|::|.:..|::||:||.|
pombe   310 VHRARLASNHMEVVVKVQYPGVMSSIDSDLNNLAYLLKASRILPKGLFLENSLAAARKELKWECD 374

  Fly   426 YDREAEYTEKFREMIAPYPEYYVPRVVRDLTTSSVLTTELVPGVPLDKCFDLSYEHRRHIAASVL 490
            |:|||.:.|:|..::....::.||.|.|:.:..||:|.|.:.|:.|.| ...|...|.||...:.
pombe   375 YEREAAFAERFGSLLKNDSDFKVPMVFREASGPSVITLEYLHGIALGK-QKYSQATRNHIGYLLT 438

  Fly   491 KLCLRELFEIECMQTDPNWSNFLYDAPSRRLMLIDFGSTRFYRHEFIRNYRRVIMSAAENNRQGV 555
            |.||||:.|...||||||||||||:..::::.|:|||::..|..:||:.|.|::::||..||:..
pombe   439 KQCLREISEYHFMQTDPNWSNFLYNGKTKKIELLDFGASIEYDEKFIKKYCRLLLAAAHRNREKC 503

  Fly   556 LEMSREMGFLTGYETKQMEQAHVDAVMILGEIFRYDGD--FDFGRQNTTERLAALVPTMVAHRLC 618
            .::|.|:|:|..:|:.||..||::::..|.|.|.:|..  :|||.|..|.|:...:|.|:..||.
pombe   504 KKLSVELGYLNNHESAQMIDAHINSIFTLAEPFAFDAPDVYDFGDQTITARVKQQIPVMLDLRLQ 568

  Fly   619 PPPEEIYSIHRKLSGIFLLCARLNVRMNCVPFYKDIVLGKFK 660
            |||||.||:||:|||.|||||:|..::.|    |::..|..|
pombe   569 PPPEETYSLHRRLSGHFLLCAKLGAKVRC----KELFSGMLK 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq8	NP_572836.1	AarF	262..641	CDD:223733	169/381 (44%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	110/250 (44%)
abc1	NP_596237.1	AarF	170..610	CDD:223733	191/454 (42%)
abc1	NP_596237.1	ABC1_ADCK3	261..511	CDD:270872	110/250 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	171	1.000	Domainoid score	I886
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I464
OMA	1	1.010	-	-		QHG53666
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		oto100441
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
TreeFam	1	0.960	-	-
	12	11.950