DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Coq8 and coq8b

DIOPT Version :9

Sequence 1:	NP_572836.1	Gene:	Coq8 / 32239	FlyBaseID:	FBgn0052649	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_002938863.1	Gene:	coq8b / 100489004	XenbaseID:	XB-GENE-956767	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	639	Identity:	278/639 - (43%)
Similarity:	399/639 - (62%)	Gaps:	57/639 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LWSNSS------------IRELIAENVAHTQQLVRSSSQNPTEELKKLQQTVKETGERGYVVAKG 85
            :||..|            |.||.||.:   :.::.||:..  .|:|.:|...::       .|..
Frog     1 MWSEVSLVLRGASRVGQAIVELQAEQL---RMVIHSSTLG--NEIKSVQAKAEQ-------CAAT 53

  Fly    86 ICSLLETKIKMSREESAISEP-AQVSSIRKSTPTAQNPASWDAANLDISSITLQEFEEILSRRNK 149
            :.:..:.::...||.|:.||| |...:|....|.|:.|.       |||..|::.....||...|
Frog    54 LFTRCQNRMPDLRERSSSSEPDASNWAIASEFPPAEEPR-------DISDGTVRASTYTLSSSGK 111

  Fly   150 DRSVSLRTPATKSNQTMPKKETSTNPGIITQDTEYVNNVLRFVAGAKVEEQPPDAQPKKKSDQPA 214
            ...|.    ...:.|....:..||..|:...:       |:....:|::        |...:|..
Frog   112 GSGVD----GVSTRQVRAYRSYSTFRGLTADE-------LKRARESKLQ--------KGTEEQGR 157

  Fly   215 IEVPELSKVAKQRKVPSSRIGRMASFGGLFAGLGLGTLNELTKGALG----LGGSTSMREA--LL 273
            .:..:||..|::||||:|||.|:|:||||..|||:|.|.|:.|.:|.    ...:.|:.|:  ||
Frog   158 SKRQKLSDRARERKVPASRISRLANFGGLAVGLGIGALTEVVKQSLNREERQDSNHSILESNTLL 222

  Fly   274 SPANAERIVDTLCKVRGAALKIGQILSIQDSSVVSPQLAKAFERVRQAADYMPDWQVERVMNTQL 338
            :.||||||||||||||||||||||:||:||::.:||||.|.||||||:||:||.||:.:|:..:|
Frog   223 NEANAERIVDTLCKVRGAALKIGQMLSLQDNNFISPQLQKIFERVRQSADFMPSWQMTKVLEDEL 287

  Fly   339 GADWRQRLKSFEDKPFAAASIGQVHRATLSDGMDVAIKIQYPGVAQSIESDIDNLVGMLKVWDVF 403
            |.|||::|:.||::|||||||||||.|.|.||.:||:||||||:|:||.||::||:.:||:....
Frog   288 GHDWREKLEYFEERPFAAASIGQVHLARLLDGREVAMKIQYPGIAESINSDVENLLSILKMSVAI 352

  Fly   404 PQGFFIDNVVRVAKRELQWEVDYDREAEYTEKFREMIAPYPEYYVPRVVRDLTTSSVLTTELVPG 468
            |.|.|.:|.|:|.::||.||.||.|||:..::||.:::..|.:.||:|:.:|||..|||.|||.|
Frog   353 PAGLFPENSVQVLQKELTWECDYTREAKSAKRFRHLLSKDPFFSVPQVIDELTTERVLTMELVSG 417

  Fly   469 VPLDKCFDLSYEHRRHIAASVLKLCLRELFEIECMQTDPNWSNFLYDAPSRRLMLIDFGSTRFYR 533
            ||||:|.::..|.|..|:.::|:|||:|:||...||||||||||.||..|.::||:|||::|.:.
Frog   418 VPLDQCVEMDQETRNQISYNILRLCLQEVFEFHFMQTDPNWSNFFYDTESNKVMLLDFGASREFG 482

  Fly   534 HEFIRNYRRVIMSAAENNRQGVLEMSREMGFLTGYETKQMEQAHVDAVMILGEIFRYDGDFDFGR 598
            .:|..:|..||.:||:.:|..||:.|:::.||||:|||..|:||:||||||||.|..|..|:||.
Frog   483 EKFTDDYIEVIKAAADGDRAKVLQKSQDLKFLTGFETKVFEEAHIDAVMILGEAFVSDVPFNFGT 547

  Fly   599 QNTTERLAALVPTMVAHRLCPPPEEIYSIHRKLSGIFLLCARLNVRMNCVPFYK 652
            ||||.|:..|:|.|:..||.|||||.||:|||::|.||:||:|...:.|...::
Frog   548 QNTTRRIHDLIPVMLKDRLTPPPEETYSLHRKMAGSFLICAKLQAVIPCKELFQ 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq8	NP_572836.1	AarF	262..641	CDD:223733	211/380 (56%)
Coq8	NP_572836.1	ABC1_ADCK3	313..563	CDD:270872	129/249 (52%)
coq8b	XP_002938863.1	ABC1_ADCK3	262..512	CDD:270872	129/249 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86731
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1457
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm47472
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980