Protein Alignment Nep6 and ECE2

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 182/763 - (23%)
• Similarity: 302/763 - (39%)
• Gaps: 162/763 - (21%)

  Fly     5 LSSITRL-VVILGVMLLKLAAAQDC------QQQLD-------------------NDTDAEVKPC 43
            |.|.|:| :|:.|..||..|....|      |...|                   ...|..|.||
Human    99 LGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPC 163

  Fly    44 ENFHQYACGNWYSNTSQRILGAHDMRSKW-----VANLKLQLIRYLEESSSTDSFSANTSVTTST 103
            |:|:|::||.|.....     ..|.||:|     :.:....::::|.|::   :|::::.....|
Human   164 EDFYQFSCGGWIRRNP-----LPDGRSRWNTFNSLWDQNQAILKHLLENT---TFNSSSEAEQKT 220

  Fly   104 AQLGTLYRCCL-------LSGQSIRTYTDALSRSGANFPLLANHTG----GSFDWVLANAALRTY 157
            .:   .|..||       |..|.:|   |.:.:.|.     .|.||    .:|..|| .|...||
Human   221 QR---FYLSCLQVERIEELGAQPLR---DLIEKIGG-----WNITGPWDQDNFMEVL-KAVAGTY 273

  Fly   158 GAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILL---LELGLRVRRAA 219
            .|...:.:.:..:.:|::..:..:......|..||..||....::.|...|   .|||:
Human   274 RATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGM------ 332

  Fly   220 LLAEKLVAFEKSLQKLL-----------PND--AEQTLVLRKPQSLKDLESQLPRLELKRYFETI 271
            ||..:..:..:.:|::|           |.|  .::..:..| .|:.:|::..|.::...:...:
Human   333 LLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHK-MSISELQALAPSMDWLEFLSFL 396

  Fly   272 LEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNH 336
            |..::......::|..:||||.:..|:  :.::|.:|:.:|:..|.......|  |.:..:.:..
Human   397 LSPLELSDSEPVVVYGMDYLQQVSELI--NRTEPSILNNYLIWNLVQKTTSSL--DRRFESAQEK 457

  Fly   337 CLEQLRKLMPGQLGRLQ---------MQLVLGESY-QDVYDTAIQQIAV-LFRDLKQQFELVLNE 390
            .||.|.......:.|.|         :...||..: :..:|...::||. :..:::..||..|.:
Human   458 LLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ 522

  Fly   391 TEVFNEDLVTRNLARDKLRAMR--------LLTPRLQDPINGGPGTPQLGGNCDA---NLLQLSL 444
            ....:|.  ||..|::|..|:.        :|.|:..|.:..|....:     |:   |:|.|..
Human   523 LVWMDEK--TRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISE-----DSFFQNMLNLYN 580

  Fly   445 SQAKLEYRQVFGEPVTSVPA------DPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTR 503
            ..||     |..:.:...|:      .|.:|||||....|.|..|.|::..|...:...|
Human   581 FSAK-----VMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPK----- 635

  Fly   504 AKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYS------- 561
            |....|:|.::.||:.||||..|..||..|.| ...|...::..|.....| :..:|:
Human   636 ALNFGGIGVVMGHELTHAFDDQGREYDKEGNL-RPWWQNESLAAFRNHTAC-MEEQYNQYQVNGE 698

  Fly   562 --NATLTVNENIADTEGLRLALDTY-----RHRS-------GATNLRTFFVAFAQNWCGT---VA 609
              |...|:.|||||..||:.|.:.|     :|..       |.||.:.|||.|||.||..   .:
Human   699 RLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPES 763

  Fly   610 STSGL--SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |..||  ..|:....||...:.|..:|...|.|...|.|||...|.:|
Human   764 SHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	167/698 (24%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	167/698 (24%)