DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nep6 and ECE2

DIOPT Version :9

Sequence 1:NP_001245645.1 Gene:Nep6 / 32234 FlyBaseID:FBgn0030425 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001093590.1 Gene:ECE2 / 9718 HGNCID:13275 Length:811 Species:Homo sapiens


Alignment Length:763 Identity:182/763 - (23%)
Similarity:302/763 - (39%) Gaps:162/763 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LSSITRL-VVILGVMLLKLAAAQDC------QQQLD-------------------NDTDAEVKPC 43
            |.|.|:| :|:.|..||..|....|      |...|                   ...|..|.||
Human    99 LGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPC 163

  Fly    44 ENFHQYACGNWYSNTSQRILGAHDMRSKW-----VANLKLQLIRYLEESSSTDSFSANTSVTTST 103
            |:|:|::||.|.....     ..|.||:|     :.:....::::|.|::   :|::::.....|
Human   164 EDFYQFSCGGWIRRNP-----LPDGRSRWNTFNSLWDQNQAILKHLLENT---TFNSSSEAEQKT 220

  Fly   104 AQLGTLYRCCL-------LSGQSIRTYTDALSRSGANFPLLANHTG----GSFDWVLANAALRTY 157
            .:   .|..||       |..|.:|   |.:.:.|.     .|.||    .:|..|| .|...||
Human   221 QR---FYLSCLQVERIEELGAQPLR---DLIEKIGG-----WNITGPWDQDNFMEVL-KAVAGTY 273

  Fly   158 GAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILL---LELGLRVRRAA 219
            .|...:.:.:..:.:|::..:..:......|..||..||....::.|...|   .|||:      
Human   274 RATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGM------ 332

  Fly   220 LLAEKLVAFEKSLQKLL-----------PND--AEQTLVLRKPQSLKDLESQLPRLELKRYFETI 271
            ||..:..:..:.:|::|           |.|  .::..:..| .|:.:|::..|.::...:...:
Human   333 LLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHK-MSISELQALAPSMDWLEFLSFL 396

  Fly   272 LEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNH 336
            |..::......::|..:||||.:..|:  :.::|.:|:.:|:..|.......|  |.:..:.:..
Human   397 LSPLELSDSEPVVVYGMDYLQQVSELI--NRTEPSILNNYLIWNLVQKTTSSL--DRRFESAQEK 457

  Fly   337 CLEQLRKLMPGQLGRLQ---------MQLVLGESY-QDVYDTAIQQIAV-LFRDLKQQFELVLNE 390
            .||.|.......:.|.|         :...||..: :..:|...::||. :..:::..||..|.:
Human   458 LLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ 522

  Fly   391 TEVFNEDLVTRNLARDKLRAMR--------LLTPRLQDPINGGPGTPQLGGNCDA---NLLQLSL 444
            ....:|.  ||..|::|..|:.        :|.|:..|.:..|....:     |:   |:|.|..
Human   523 LVWMDEK--TRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISE-----DSFFQNMLNLYN 580

  Fly   445 SQAKLEYRQVFGEPVTSVPA------DPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTR 503
            ..||     |..:.:...|:      .|.:|||||....|.|..|.|::..|...:...|     
Human   581 FSAK-----VMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPK----- 635

  Fly   504 AKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYS------- 561
            |....|:|.::.||:.||||..|..||..|.| ...|...::..|.....| :..:|:       
Human   636 ALNFGGIGVVMGHELTHAFDDQGREYDKEGNL-RPWWQNESLAAFRNHTAC-MEEQYNQYQVNGE 698

  Fly   562 --NATLTVNENIADTEGLRLALDTY-----RHRS-------GATNLRTFFVAFAQNWCGT---VA 609
              |...|:.|||||..||:.|.:.|     :|..       |.||.:.|||.|||.||..   .:
Human   699 RLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPES 763

  Fly   610 STSGL--SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |..||  ..|:....||...:.|..:|...|.|...|.|||...|.:|
Human   764 SHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nep6NP_001245645.1 PepO 35..655 CDD:226118 169/705 (24%)
M13 40..653 CDD:189000 167/698 (24%)
ECE2NP_001093590.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..64
M13 160..809 CDD:189000 167/698 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.020

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