Protein Alignment Nep6 and ECEL1

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_004817.2
• Gene: ECEL1 / 9427
• HGNCID: 3147
• Length: 775
• Species: Homo sapiens
• Alignment Length: 795
• Identity: 190/795 - (23%)
• Similarity: 287/795 - (36%)
• Gaps: 241/795 - (30%)

  Fly    11 LVVILGVML-LKL---------AAAQDCQQQ---------LDNDTDAEVKPCENFHQYACGNWYS 56
            |..||..|| ||.         |..:.|.::         |..:.||.:.||::|:.:|||.|
Human    72 LCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGW-- 134

  Fly    57 NTSQRILGAHDMRSKWVANLKL--------------QLIRYLEESSSTDSFSANTSVTTSTAQLG 107
                       :|...:.:.||              :|.|.|.........:|...|.
Human   135 -----------LRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVR------- 181

  Fly   108 TLYRCCLLSGQSIRTYTDALSRSGANFPLL--ANHTGGSFDWVLANAALR--------------- 155
            ..:|.||    .:|    .:.|.|.. |:|  ....||   |.|..|..|
Human   182 AFFRSCL----DMR----EIERLGPR-PMLEVIEDCGG---WDLGGAEERPGVAARWDLNRLLYK 234

  Fly   156 ---TYGAQGLWRLLVKDNWQSADQRIFYM------LPPKFDLLGRDDELNEFL--YQRYLKILLL 209
               .|.|..|:.|.|..:.:::.:.:..:      ||.:...|.:|::..:.|  |:.:::.:|.
Human   235 AQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLS 299

  Fly   210 ELGLRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLV---------LRKPQS-------LKDLESQ 258
            .||..            |.|:..|::|  ..||.|.         ||:..|       |..|:..
Human   300 LLGAD------------AVEQKAQEIL--QVEQQLANITVSEHDDLRRDVSSMYNKVTLGQLQKI 350

  Fly   259 LPRLELKRYFETILEGIDWDSKTLLLVADLDYLQGLQRL--------------------LAEHTS 303
            .|.|..|...:.|.:. |:..:..:::...||:|.:.:|                    |:||.|
Human   351 TPHLRWKWLLDQIFQE-DFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLS 414

  Fly   304 DPMVLSTWLLLQLPAYFELRLHD-------DDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGES 361
            .|              |...||:       .||.......||.|..:.....||    .|.:.|.
Human   415 PP--------------FREALHELAQEMEGSDKPQELARVCLGQANRHFGMALG----ALFVHEH 461

  Fly   362 YQDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGP 426
            :.......:||   |..|:|......|.|.:..  |..||..||.||:.|.::.
Human   462 FSAASKAKVQQ---LVEDIKYILGQRLEELDWM--DAETRAAARAKLQYMMVMV----------- 510

  Fly   427 GTPQLGGNCDA-------------------NLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAY 472
            |.|......||                   |.::.|:..:..:.||...:....:|  |.::|||
Human   511 GYPDFLLKPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLP--PQALNAY 573

  Fly   473 YRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLS-AGLGYILAHEMVHAFDLDGLNYDATGQLA 536
            |....|::..|.|::...|.      :.|....|: .|:|.|:.||:.|.:|..|..||.:|.|.
Human   574 YLPNKNQMVFPAGILQPTLY------DPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLL 632

  Fly   537 NGQWSARAIIRFGLRAGCYLGVRYSNATL---------TVNENIADTEGLRLALDTYRH------ 586
            : .|:..:..||..:|.|.:.: |.|.|:         |:.|||||..||:||...|:.
Human   633 H-WWTEASYSRFLRKAECIVRL-YDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHG 695

  Fly   587 ------RSGATNLRTFFVAFAQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFEC 640
                  |...|:.:.||:|||||||....|.|...|     ||....||...|....|||..|.|
Human   696 PEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHC 760

  Fly   641 KATSQMNPVNKCHIW 655
            ...|.|||.:||.:|
Human   761 PKDSPMNPAHKCSVW 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	176/743 (24%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	176/743 (24%)