DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and ece2b

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	795	Identity:	186/795 - (23%)
Similarity:	311/795 - (39%)	Gaps:	196/795 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PLSSITRL-VVILGVMLLKLAAAQDCQ-----------------------------QQLDNDTDA 38
            ||...|:| ||:.|::|..|.|...|.                             :.||...|
Zfish    53 PLGRRTQLEVVLAGLLLASLLALFGCAVTLGVRYNRDPARSICLTEACVTVASKIVEALDRSAD- 116

  Fly    39 EVKPCENFHQYACGNWYSNTSQRILGAHDMRSKW-----VANLKLQLIRYLEESSSTDSFSANTS 98
               ||::|:|||||.|.....     ..|.||:|     :.:....::::|.|:.:.:|.|....
Zfish   117 ---PCQDFYQYACGGWVRKNP-----LPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAER 173

  Fly    99 VTTSTAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPL--LANHTGGSFDWVLANA--------A 153
            .|.|      .|..||        ....:...||. ||  |....||   |.:..:        .
Zfish   174 KTQS------YYLSCL--------NEQRIEELGAQ-PLMDLITKIGG---WNITESWDKENFLDV 220

  Fly   154 LR----TYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRD---DELNEFLYQRYLKILLLEL 211
            |:    .|.||..:.:.|..:.::::..:..:......|..||   ::.||.:.:.||. .::||
Zfish   221 LKIISGPYRAQPFFTVSVSVDPKNSNSNVIQVDQSGLFLPSRDYYLNKTNEKVLKAYLD-YMVEL 284

  Fly   212 GLRV------RRAALLAEKLVAFEKSLQKL-LPND--AEQTLVLRKPQSLKDLESQLPRLELKRY 267
            ||.:      .|..:  ::::.||.:|..: :|.|  .::..:..| .::.||:...|.:|...|
Zfish   285 GLLLGGDKNSTRGQM--QQILDFETALANITVPQDERRDEEKIYHK-ITIADLQVLAPAIEWLDY 346

  Fly   268 FETILEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLST---WLLLQ-----LPAYFELRL 324
            ..::|..::.:....::|...:|:|.:..|:  :.:|..:|:.   |.|:|     |...||
Zfish   347 LNSVLSPLELNDTEPVVVYAKEYMQQVSELI--NKTDHSLLNNYMIWNLVQKGASSLDQRFE--- 406

  Fly   325 HDDDKL-----GNQRN------HCLEQLRKLMPGQLGRLQMQLVLGESYQDV------------- 365
            :..|||     |.:::      .|:......:...||.|.::....:..:::
Zfish   407 NAQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGR 471

  Fly   366 ---------YDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMR--------- 412
                     ..:.|.|...:..:::..|:..|::.:..:|.  ||..|:||..|:.
Zfish   472 NVNSTVHNLMFSVITQAEGMINEIRTAFKGALDDLKWMDEQ--TRQAAKDKADAIYDMIGFPDFI 534

  Fly   413 LLTPRLQDPINGGPGTPQLGGNCDANLLQLSLSQAKLEYRQVFGEPVTSVP------ADPLSVNA 471
            |.:..|.|..:|...|       :.|..|..::......| |..:.:...|      ..|.:|||
Zfish   535 LDSKELDDVYDGYEVT-------EDNFFQNMINFYNFSAR-VMADQLRKPPNRDQWSMTPPTVNA 591

  Fly   472 YYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLA 536
            ||....|.|..|.|::..|...|...|     |....|:|.::.||:.||||..|..||..|.|
Zfish   592 YYMPTKNGIVFPAGILQAPFYAQDHPK-----ALNFGGIGVVMGHELTHAFDDQGREYDKDGNL- 650

  Fly   537 NGQWSARAIIRFGLRAGCYLGVRYSNATL---------TVNENIADTEGLRLALDTYR---HRSG 589
            ...|...::..|..|..|.:. :|:..|:         |:.|||||..||:.|...||   .::|
Zfish   651 RSWWQNSSVEAFKNRTECMVD-QYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQKNG 714

  Fly   590 ---------ATNLRTFFVAFAQNWCGTVASTS---GL--SQHAGHAERVNNVVGNMPEFGDTFEC 640
                     .||.:.|||.|||.||......|   ||  ..|:....||...:.|.|||.:.|:|
Zfish   715 EEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQC 779

  Fly   641 KATSQMNPVNKCHIW 655
            ...|.||..::|.:|
Zfish   780 PLGSSMNSGHRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	172/732 (23%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	170/725 (23%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020