DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep6 and MMEL1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	768	Identity:	172/768 - (22%)
Similarity:	290/768 - (37%)	Gaps:	218/768 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LAAAQDCQQQLDNDTDAEVKPCENFHQYACGNW-----YSNTSQRILGAHDMRSKWVANLKLQLI 81
            :|||:..|     :.|...:||::|:|:|||.|     ...|:.|......:|.:    |::.|.
Human    96 IAAARILQ-----NMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDE----LEVILK 151

  Fly    82 RYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPLLA-------- 138
            ..||.|::.|        ..:..:..||||.|:  .||:      :.:.|:. |||.
Human   152 AVLENSTAKD--------RPAVEKARTLYRSCM--NQSV------IEKRGSQ-PLLDILEVVGGW 199

  Fly   139 -------NHTGGSFDWVLAN--AALRT-YGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRD- 192
                   |.|.| .:|.|..  |.:.: :..:.|..|.:.::.|::.:.|.|:..|...:..|:
Human   200 PVAMDRWNETVG-LEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREY 263

  Fly   193 ---DELNEFLYQRYLKI------LLLELGLRVRRAALLAEKLV---AFEKSLQK-LLPNDAEQTL 244
               ...|..:.:.||:.      ||.|.....|.:.|:.|.:|   ..|..|.| .:|.:....:
Human   264 YFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDV 328

  Fly   245 V-LRKPQSLKDLESQ--LPRLELKRYFETILEGIDWDSKTLLL------VADLDYLQGLQRLLAE 300
            : |.....|::|:||  |.......:.:|:|..:    |..||      |..:.|||.|:.::
Human   329 IALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSV----KIKLLPDEEVVVYGIPYLQNLENII-- 387

  Fly   301 HTSDPMVLSTWLLLQLPAYFELRLHDDDKLG--NQR----------------------NHCLEQL 341
            .|.....:..:|:.:|..         |::|  :||                      ..|:..:
Human   388 DTYSARTIQNYLVWRLVL---------DRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYV 443

  Fly   342 RKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLF----------------------RDLKQQF 384
            ...|...:|.|.::.......:.:....|.::..:|                      ..:::|.
Human   444 NSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQI 508

  Fly   385 ---ELVLNETE----------VFNEDLVTRN-LARDKLRAMRLLTPRLQDPINGGPGTPQLGGNC 435
               :.:|.|..          .|:|||...| |...|:.|.|.|. :|::.:
Human   509 GHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLR-KLREKV------------- 559

  Fly   436 DANLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEA 500
            |.||             .:.|..|         |||:|....|:|..|.|::..|..    |||
Human   560 DPNL-------------WIIGAAV---------VNAFYSPNRNQIVFPAGILQPPFF----SKE- 597

  Fly   501 DTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGC--YLGVRYS-- 561
            ..:|....|:|.::.||:.|.||.:|.|:|..|.:.: .||..:...|..::.|  |....||
Human   598 QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMD-WWSNFSTQHFREQSECMIYQYGNYSWD 661

  Fly   562 -------NATLTVNENIADTEGLRLALDTY----------RHRSG--ATNLRTFFVAFAQNWCGT 607
                   |...|:.|||||..|:|.|...|          :...|  .|:.:.||:.:||.|||:
Human   662 LADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGS 726

  Fly   608 VASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            ......:..     |:....||...:.|:..|.|||.|...:.|:|..:|.:|
Human   727 YRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	167/753 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	165/746 (22%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	168/760 (22%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	165/744 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920