DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep6 and ece1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	719	Identity:	171/719 - (23%)
Similarity:	292/719 - (40%)	Gaps:	164/719 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKW--VANL---KLQLIRYLEESSSTDSFSAN 96
            |..|.||::|:.:|||.|     .|.....:.:|:|  .:||   .:.:::.|.|::|..|.|.
Zfish    98 DRSVDPCQDFYNFACGGW-----MRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSR- 156

  Fly    97 TSVTTSTAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPL--LANHTGGSFDWVLANAALRTYGA 159
               ....||  ..|:.|:...:        :...||. ||  |.|.|||             :|.
Zfish   157 ---AEQKAQ--WYYQACMNESK--------IEELGAK-PLQDLINQTGG-------------WGL 194

  Fly   160 QGLWRLLVKDNWQ-------------------------SADQRIFYMLPPKFDLLGRDDELNEFL 199
            :|.|.   |||:|                         |::..|..:......|..|:..||:..
Zfish   195 KGPWE---KDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNKTA 256

  Fly   200 YQRYLKI---LLLELGLRV----RRAALLAEKLVAFEKSLQKLLPNDAE---QTLVLRKPQSLKD 254
            .::||..   .|:|||:.:    ..:..:.|:::.||.:|..:.....|   :..:..|.|: |:
Zfish   257 NEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQA-KE 320

  Fly   255 LESQLPRLELKRYFETILEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAY 319
            |.:..|.::...:..::...::.::...::|...:|||.:..|::  .::..||:.::::::...
Zfish   321 LATLAPAIDWMPFLSSVFAPVELNNSEPVVVYAKEYLQKVSELIS--NTNKSVLNNYMIMKVVRK 383

  Fly   320 FELRLHDDDKLGNQRNHCLEQL----RKLMPGQLGRLQMQLVLGESYQDVYDTAIQ-QIAVLFRD 379
            ....|  |.|..:.....||.:    :..||      :.:|.:.::     |:|:. .:..||
Zfish   384 MVSIL--DQKFQDAEQRFLEVMYGTKKSCMP------RWKLCVSDT-----DSALGFALGALF-- 433

  Fly   380 LKQQFELVLNETEVFNEDLVT--RNLARDKLRAMRLLTPRLQ-------DPINGGPGTPQLGGN- 434
            :|..|.   .:::.|.||:|:  :....|.|:.:..:.|..:       |.|....|.|:...|
Zfish   434 VKATFS---EDSKAFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNP 495

  Fly   435 -------CDANLLQLSLSQAKLEY----RQVFGEPVTSVP------ADPLSVNAYYRLKLNRIEL 482
                   .|.:::.....|..:.|    .:|..:.:...|      ..|.:|||||....|.:.|
Zfish   496 KELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVL 560

  Fly   483 PLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIR 547
            |.|:...|..     ..|..:|....|:|.::.||:.||||..|..||..|.||. .|...::..
Zfish   561 PAGIFQAPFY-----NHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAK-WWQNSSVEA 619

  Fly   548 FGLRAGCYLGVRYSNATL---------TVNENIADTEGLRLALDTYRH------------RSGAT 591
            |..:..|.: .:|||.::         |:.|||||..||..|...|.:            ..|..
Zfish   620 FQHQTQCMV-EQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMN 683

  Fly   592 NLRTFFVAFAQNWCGT---VASTSGL--SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNK 651
            |.:.|||.|||.||..   .:|..|:  ..|:....||...:.|..||.:.|.|||.|.|||..|
Zfish   684 NHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRK 748

  Fly   652 CHIW 655
            |.:|
Zfish   749 CELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	170/717 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	168/712 (24%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	170/717 (24%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	168/712 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020