DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep6 and Ecel1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	193/795 - (24%)
Similarity:	297/795 - (37%)	Gaps:	241/795 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVVILGVML-LKL----------AAAQDCQQQ---------LDNDTDAEVKPCENFHQYACGNWY 55
            |..||..|| ||.          |..:.|.::         |..:.||.:.||::|:.:|||.|
  Rat    72 LCAILAAMLALKYLGPGAAGTGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGW- 135

  Fly    56 SNTSQRILGAHDMRSKWVANLKL--------------QLIRYLEESSSTDSFSANTSVTTSTAQL 106
                        :|...:.:.||              :|.|.|...:.....:|...|.
  Rat   136 ------------LRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVR------ 182

  Fly   107 GTLYRCCLLSGQSIRTYTDALSRSGANFPLL--ANHTGGSFDWVLANAALR-------------- 155
             ..:|.||    .:|    .:.|.|.. |:|  ....||   |.|..||.|
  Rat   183 -AFFRSCL----DMR----EIERLGPR-PMLEVIEDCGG---WDLGGAADRPGAARWDLNRLLYK 234

  Fly   156 ---TYGAQGLWRLLVKDNWQSADQRIFYM------LPPKFDLLGRDDELNEFL--YQRYLKILLL 209
               .|.|..|:.|.|..:.:::.:.:..:      ||.:...|.:|:|..:.|  |:.:::.||.
  Rat   235 AQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVFMERLLR 299

  Fly   210 ELGLRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLV---------LRKPQS-------LKDLESQ 258
            .||..            |.|:..|::|  ..||.|.         ||:..|       |..|:..
  Rat   300 LLGAD------------AVEQKAQEIL--QLEQRLANISVSEYDDLRRDVSSVYNKVTLGQLQKI 350

  Fly   259 LPRLELKRYFETILEGIDWDSKTLLLVADLDYLQGLQRL--------------------LAEHTS 303
            .|.|:.|...:.|.:. |:..:..:::...||:|.:.:|                    |:||.|
  Rat   351 TPHLQWKWLLDQIFQE-DFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLS 414

  Fly   304 DPMVLSTWLLLQLPAYFELRLHD--DDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLG-----ES 361
            .|              |...||:  .:..||.:.   ::|.::..||..| ...:.||     |.
  Rat   415 PP--------------FREALHELAKEMEGNDKP---QELARVCLGQANR-HFGMALGALFVHEH 461

  Fly   362 YQDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGP 426
            :.......:||   |..|:|......|.|.:..  |..|:..||.||:.|.::.
  Rat   462 FSAASKAKVQQ---LVEDIKYILGQRLEELDWM--DAQTKAAARAKLQYMMVMV----------- 510

  Fly   427 GTPQLGGNCDA-------------------NLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAY 472
            |.|......:|                   |.::.|:..:..:.||...:....:|  |.::|||
  Rat   511 GYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLP--PQALNAY 573

  Fly   473 YRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLS-AGLGYILAHEMVHAFDLDGLNYDATGQLA 536
            |....|::..|.|::...|.      :.|....|: .|:|.|:.||:.|.:|..|..||.:|.|.
  Rat   574 YLPNKNQMVFPAGILQPTLY------DPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLL 632

  Fly   537 NGQWSARAIIRFGLRAGCYLGVRYSNATL---------TVNENIADTEGLRLALDTYR------- 585
            : .|:..:..||..:|.|.:.: |.|.|:         |:.|||||..||:||...|:
  Rat   633 H-WWTEASYSRFLHKAECIVRL-YDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHG 695

  Fly   586 -----HRSGATNLRTFFVAFAQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFEC 640
                 ||...|:.:.||:|||||||....|.|...|     ||....||...|....|||..|.|
  Rat   696 PEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHC 760

  Fly   641 KATSQMNPVNKCHIW 655
            ...|.||||:||.:|
  Rat   761 PKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	182/749 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	179/742 (24%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	179/742 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920