DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and PHEX

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	775	Identity:	168/775 - (21%)
Similarity:	294/775 - (37%)	Gaps:	188/775 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VILGVM-------LLKLAAAQ------DCQQ---QLDNDTDAEVKPCENFHQYACGNWYSNTSQR 61
            ::||.:       ||.|.|.|      :|.:   .:.:..:..|.||:||.::||..|.||...
Human    31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPI- 94

  Fly    62 ILGAHDMRS----KWVA-NLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIR 121
               ..||.|    .|:. |:.|:|...||:|.|      ....|.:..:...||..|:
Human    95 ---PEDMPSYGVYPWLRHNVDLKLKELLEKSIS------RRRDTEAIQKAKILYSSCM------- 143

  Fly   122 TYTDALSRSGANFPLLANHTGGSFDWVLANAALRTYGAQGLW----------------------- 163
             ...|:.::.|. |||.......|.|.:..:.:   |.:|:|
Human   144 -NEKAIEKADAK-PLLHILRHSPFRWPVLESNI---GPEGVWSERKFSLLQTLATFRGQYSNSVF 203

  Fly   164 -RLLVKDNWQSADQRIFYMLPPKFDLLGRDDELN---------EFLYQRYLKILLLELGLRVRRA 218
             ||.|..:.:::::.|..:......|..|:|.|:         :.||:..:...:| ||....||
Human   204 IRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL-LGANSSRA 267

  Fly   219 ALLAEKLVAFE-KSLQKLLPNDAEQTLVLRKPQSLKDLESQLPRLELKRYFETILEGIDWDSKTL 282
            ....:.::..| |..:.::|::...:..:....::.:|.:.:|:.:...|.:.::     |::..
Human   268 EHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVI-----DTRLY 327

  Fly   283 LLVADL-----------DYLQGLQRLLAEHTSDPMV-LSTWLLL-----QLPAYFELR------- 323
            ..:.|:           .|.:.|.|:|.......:. ...|.::     .|...|:.|
Human   328 PHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRV 392

  Fly   324 LHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVL 388
            :.....|..|.:.|:..:...:|..:|::.:.:...|..:::.:..::.:...|.|:
Human   393 IQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM-------- 449

  Fly   389 NETEVFNE--DLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGN---CDANLLQLSLSQAK 448
              .|..||  |..|:..|::|.||           :....|.|:...|   .:.:|..:..|:|.
Human   450 --LEKENEWMDAGTKRKAKEKARA-----------VLAKVGYPEFIMNDTHVNEDLKAIKFSEAD 501

  Fly   449 -----LEYRQVFGE----------PVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSK 498
                 |:.|:...:          |.|....:|.:|||:|....|:|..|.|.:..|...
Human   502 YFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFW----- 561

  Fly   499 EADTRAKLSAG-LGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSN 562
            ..:....||.| :|.|:.||..|.||.:|..||..|.| :..||..:..:|..:..|.:. :|||
Human   562 GTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNL-DPWWSTESEEKFKEKTKCMIN-QYSN 624

  Fly   563 -----------ATLTVNENIADTEGLRLALDTYR-----HRSGA----------TNLRTFFVAFA 601
                       ...|:.|||||..|||.|...||     .|.|.          ||.:.||:::|
Human   625 YYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYA 689

  Fly   602 QNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMN-PVNKCHIW 655
            ...|.:....:...|     |:....|||..:.|..||...|.|...|.|| .::.|.:|
Human   690 HVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	159/735 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	158/728 (22%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	158/728 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920