DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nep7

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	778	Identity:	185/778 - (23%)
Similarity:	297/778 - (38%)	Gaps:	191/778 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSSITRLVVI--LGVMLLKLAAAQDCQQQLDNDTDAE-------------------------VKP 42
            :||..||.:.  |.|.:|......||:.:...|...|                         |.|
  Fly     4 ISSYFRLPLYTRLAVCILICVILNDCEARSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDP 68

  Fly    43 CENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLG 107
            |::|:::||||| .|........|  |...:.::...|:...|:..:....:...:|:.......
  Fly    69 CDDFYEFACGNW-KNVKTPRQSPH--RRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQ 130

  Fly   108 TLYRCCLLSGQSIRTYTD----ALSRSGANFPLLANH--TGGSFDWVLANAALRTYGAQGLWRLL 166
            ..|..||.:....|...|    ::.||...||.:...  ...||.|...:|.|..||.    |.|
  Fly   131 RFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGV----RSL 191

  Fly   167 VKDNWQSADQRIFYMLP-----PKFDL--LGRDD---------------ELNEFLYQRYLKILLL 209
            :.:.          :||     |.|.|  ||.|.               :|||...:.|||
  Fly   192 IHEE----------ILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLK---- 242

  Fly   210 ELGLRVRRAALLAEKLVAF---EKSLQKLLPNDAEQTLVLRKPQSLKDLESQLPRL-ELKRYFET 270
            |..|.....:.:.|.:.||   ..|::....:|.:      |...|.::| ::||. :.:.|:|.
  Fly   243 EYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRD------KCDLLSEIE-EVPRFGQWRSYYEI 300

  Fly   271 ILEGID-WDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKL---- 330
            ...||| ::..:.....|..|:: |.::.|:||.   .::.:|.::    |..|:  ||||
  Fly   301 AWNGIDFYNGSSGGEFCDFYYVE-LDKVCAKHTE---AVANYLAMR----FLYRM--DDKLKEPK 355

  Fly   331 --GNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVLNETEV 393
              .:|:.:||..::..:|....||.|    .|.:.|...:.|..:....|..::|   :|...|.
  Fly   356 QPEDQKVNCLMIVQMTLPNLFNRLYM----AEHFTDEKHSEISDMVTEMRKAQRQ---ILESVEW 413

  Fly   394 FNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNC-----DANLLQLSLSQAKLEYR- 452
            .  |..||..|..|...:        .|:.|.....:|....     :..:::.|.:|:.:..|
  Fly   414 L--DAETRAEALSKEAGI--------TPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLINLRV 468

  Fly   453 ------QVFGEPVTSVPAD--PLS------VNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTR 503
                  :..|.....:|.|  ||:      |||:|....|.:.:..|::..|...:....
  Fly   469 LGTYLHRYAGLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPD----- 528

  Fly   504 AKLSAG-LGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSNATL-- 565
             .|..| :||::.||:.|.||.:|.::|:.|::.: .||.::...|..||.||  |.|.|..|
  Fly   529 -SLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRD-WWSRKSEAVFQERAQCY--VDYFNQYLIP 589

  Fly   566 ----------TVNENIADTEGLRLALDTYRH------RSGA-----------------TNLRTFF 597
                      |.:|||||..|||.||..||:      ||||                 :..:.||
  Fly   590 EINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFF 654

  Fly   598 VAFAQNWCGTVASTSGLSQ----HAGHAERVNNVVGNMPEFGDTFECKATSQMNP-VNKCHIW 655
            |.|||.||..........:    |.....||...|.|..:|.:.::|...|.|:| ...|.:|
  Fly   655 VGFAQLWCADYEPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	175/744 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	172/712 (24%)
Nep7	NP_651603.1	PepO	60..717	CDD:226118	173/720 (24%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	172/712 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850