DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nep5

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	850	Identity:	190/850 - (22%)
Similarity:	305/850 - (35%)	Gaps:	262/850 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KPPLSSITRLVVILGVMLL----------KLAAAQDCQQ-------QLDNDTDAEVKPCENFHQY 49
            |..|..:..||:||.:.::          .:..:::|.:       .:|..||    |||:|:|:
  Fly    99 KVVLGGLLALVIILLIAIIVISLGLKKSSSICRSKECLRTAASLIYAMDEQTD----PCEDFYQF 159

  Fly    50 ACGNW----------YSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTA 104
            .||.|          .||...|...||.||          ::|....|:.|      .|...:..
  Fly   160 TCGRWANEHPRPDSVTSNDWFRERQAHIMR----------VVREFLRSNIT------KSEPEAVG 208

  Fly   105 QLGTLYRCC----LLSGQSIRTYTDALSRSGAN-FPLLANHTGGSFDWVLANAALRTYGAQGLWR 164
            :..|:||.|    ||..:.:....:.|.|.|.. .|...|.|.||.......||
  Fly   209 KAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAA----------- 262

  Fly   165 LLVKDNW----QSADQRI-------FYMLPPKFD------LLG----------RDDELNEFLYQR 202
             .||.||    .|..|.:       |.:.|..|:      .||          .:|:.::.|.:.
  Fly   263 -NVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKI 326

  Fly   203 YLKILLLE-------------------------------------------------------LG 212
            :.|.:.::                                                       ||
  Fly   327 HRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLG 391

  Fly   213 LR--VRRAALLAEKLVAFE---KSLQKLLPNDAEQTLVLRKPQSLKDLESQLPR------LEL-K 265
            :.  |::...:|.|:..|:   :::.|...|.|:..:.:    :|:||::|..:      |.: .
  Fly   392 ITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYI----TLQDLQNQTDKNIAPKTLPIWV 452

  Fly   266 RYFETILEG------IDWDSKTLLLV--ADLDYLQGLQRLL----AEHTSDPMVLSTWLLLQLPA 318
            ||.|.||:|      |.......::.  ||:.|||.:...|    |.|....:.|||...|.|..
  Fly   453 RYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHT 517

  Fly   319 YFELRLHDDD----KLGNQRN-----HCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIA 374
            ...:||...:    .:|.:.:     :|...:..|    || :.:..||.::  |.....:.::.
  Fly   518 SSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSL----LG-MAVSYVLADA--DFTKEKLPKVE 575

  Fly   375 VLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQL-------- 431
            .:..|:::.|:.::..|...  |..|:.....|...|:...        |.|  |.|
  Fly   576 RMLSDIRRSFDRLVKSTSWM--DAATKRKTIQKSAEMKSFI--------GFP--PWLRNASVLNA 628

  Fly   432 ---GGNCDA-----NLLQLSLSQAKLEYRQV-FGEPV---TSVPADPLSVNAYYRLKLNRIELPL 484
               |...:|     ||:.....|...:..:: ..||:   ||    |.:|||::..:.|.|.:|:
  Fly   629 YYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPEPIGWATS----PSNVNAFHTFQSNAITVPI 689

  Fly   485 GLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFG 549
            .::..|..      :....|.....:|.||.||:.|.||..|..:|..|.:.. .||.|.|..:.
  Fly   690 AILQYPFY------DLGLEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVE-WWSNRTIDEYV 747

  Fly   550 LRAGCYLGV----------RYSNATLTVNENIADTEGLRLALDTY--------RHRSGATNL--- 593
            .|..|::..          .|.:..||:.|||||..|:|.|...|        |.||....|
  Fly   748 NRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHY 812

  Fly   594 ---RTFFVAFAQNWCGT---VASTSGLS-QHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVN- 650
               :.||::|...||.|   .||...|: .|.....|:..|:.|..||..||:|...:.|||..
  Fly   813 SHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQP 877

  Fly   651 KCHIW 655
            ||.||
  Fly   878 KCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	180/798 (23%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	177/791 (22%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	181/801 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	178/794 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920