Protein Alignment Nep6 and MME

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 172/773 - (22%)
• Similarity: 299/773 - (38%)
• Gaps: 175/773 - (22%)

  Fly     5 LSSITRLVVILGVMLLKLAAAQD---CQQ--------QLDNDTDAEVKPCENFHQYACGNWYS-- 56
            ||.:..|:.|:.|.::.|.|..|   |:.        :|..:.||..:||.:|.:||||.|..
Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRN 95

  Fly    57 ---NTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQ 118
               .||.|......:|.:    |::.|...|:|..:.|        ..:..:...|||.|:
Human    96 VIPETSSRYGNFDILRDE----LEVVLKDVLQEPKTED--------IVAVQKAKALYRSCI---- 144

  Fly   119 SIRTYTDALSRSGANFPLL----------------ANHTGGSFDWVLANAALRT-YGAQGLWRLL 166
                ...|:...|.. |||                ....|.|:....|.|.|.: ||.:.|..|.
Human   145 ----NESAIDSRGGE-PLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLF 204

  Fly   167 VKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQR----YLKILLL---------ELGLRVRRA 218
            |..:.:::...:.::..|:..|..||......:|:.    |:..::.         .|.:...:.
Human   205 VGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQL 269

  Fly   219 ALLAEKLVAFEKSLQKLL--PNDAEQTLVLRKPQSLKDLESQLPRLELK-------RYFETILE- 273
            ||...|::..||.:....  |.|....::|....:|..:::.. .||:.       .:...|:.
Human   270 ALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNF-SLEINGKPFSWLNFTNEIMST 333

  Fly   274 -GIDWDSKTLLLVADLDYLQGLQRLLAEHTS-DPMVLSTW-LLLQLPA-----YFELR------L 324
             .|...::..::|...:||..|:.:|.:::: |...|.:| .::.|.:     |.|.|      |
Human   334 VNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKAL 398

  Fly   325 HDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLF-----------R 378
            :...........|...:...|...:|||.::.......:.|.:..|.||..:|           .
Human   399 YGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDA 463

  Fly   379 DLKQQFE---LVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLL 440
            :.|::.|   |.:.|...:.:|:|:.:   :||....|.....:|             ....|::
Human   464 ETKKRAEEKALAIKERIGYPDDIVSND---NKLNNEYLELNYKED-------------EYFENII 512

  Fly   441 Q-LSLSQAK--LEYRQ-------VFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQ 495
            | |..||:|  .:.|:       :.|..|         |||:|....|:|..|.|::..|....|
Human   513 QNLKFSQSKQLKKLREKVDKDEWISGAAV---------VNAFYSSGRNQIVFPAGILQPPFFSAQ 568

  Fly   496 CSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYL---- 556
            .|...:     ..|:|.::.||:.|.||.:|.|::..|.|.: .|:.::...|..::.|.:
Human   569 QSNSLN-----YGGIGMVIGHEITHGFDDNGRNFNKDGDLVD-WWTQQSASNFKEQSQCMVYQYG 627

  Fly   557 -------GVRYSNATLTVNENIADTEGLRLALDTYRH---RSGATNL---------RTFFVAFAQ 602
                   |.::.|...|:.|||||..||..|...|::   ::|...|         :.||:.|||
Human   628 NFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQ 692

  Fly   603 NWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            .||||......::.     |:....|:...:.|..||.:.|.|:..|.|||..||.:|
Human   693 VWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	158/723 (22%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	158/721 (22%)