DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and MME

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	773	Identity:	172/773 - (22%)
Similarity:	299/773 - (38%)	Gaps:	175/773 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSSITRLVVILGVMLLKLAAAQD---CQQ--------QLDNDTDAEVKPCENFHQYACGNWYS-- 56
            ||.:..|:.|:.|.::.|.|..|   |:.        :|..:.||..:||.:|.:||||.|..
Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRN 95

  Fly    57 ---NTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQ 118
               .||.|......:|.:    |::.|...|:|..:.|        ..:..:...|||.|:
Human    96 VIPETSSRYGNFDILRDE----LEVVLKDVLQEPKTED--------IVAVQKAKALYRSCI---- 144

  Fly   119 SIRTYTDALSRSGANFPLL----------------ANHTGGSFDWVLANAALRT-YGAQGLWRLL 166
                ...|:...|.. |||                ....|.|:....|.|.|.: ||.:.|..|.
Human   145 ----NESAIDSRGGE-PLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLF 204

  Fly   167 VKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQR----YLKILLL---------ELGLRVRRA 218
            |..:.:::...:.::..|:..|..||......:|:.    |:..::.         .|.:...:.
Human   205 VGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQL 269

  Fly   219 ALLAEKLVAFEKSLQKLL--PNDAEQTLVLRKPQSLKDLESQLPRLELK-------RYFETILE- 273
            ||...|::..||.:....  |.|....::|....:|..:::.. .||:.       .:...|:.
Human   270 ALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNF-SLEINGKPFSWLNFTNEIMST 333

  Fly   274 -GIDWDSKTLLLVADLDYLQGLQRLLAEHTS-DPMVLSTW-LLLQLPA-----YFELR------L 324
             .|...::..::|...:||..|:.:|.:::: |...|.:| .::.|.:     |.|.|      |
Human   334 VNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKAL 398

  Fly   325 HDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLF-----------R 378
            :...........|...:...|...:|||.::.......:.|.:..|.||..:|           .
Human   399 YGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDA 463

  Fly   379 DLKQQFE---LVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLL 440
            :.|::.|   |.:.|...:.:|:|:.:   :||....|.....:|             ....|::
Human   464 ETKKRAEEKALAIKERIGYPDDIVSND---NKLNNEYLELNYKED-------------EYFENII 512

  Fly   441 Q-LSLSQAK--LEYRQ-------VFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQ 495
            | |..||:|  .:.|:       :.|..|         |||:|....|:|..|.|::..|....|
Human   513 QNLKFSQSKQLKKLREKVDKDEWISGAAV---------VNAFYSSGRNQIVFPAGILQPPFFSAQ 568

  Fly   496 CSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYL---- 556
            .|...:     ..|:|.::.||:.|.||.:|.|::..|.|.: .|:.::...|..::.|.:
Human   569 QSNSLN-----YGGIGMVIGHEITHGFDDNGRNFNKDGDLVD-WWTQQSASNFKEQSQCMVYQYG 627

  Fly   557 -------GVRYSNATLTVNENIADTEGLRLALDTYRH---RSGATNL---------RTFFVAFAQ 602
                   |.::.|...|:.|||||..||..|...|::   ::|...|         :.||:.|||
Human   628 NFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQ 692

  Fly   603 NWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            .||||......::.     |:....|:...:.|..||.:.|.|:..|.|||..||.:|
Human   693 VWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	161/730 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	158/723 (22%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	158/721 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920