DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nepl16

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	142/724 - (19%)
Similarity:	247/724 - (34%)	Gaps:	226/724 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AAAQDCQQQLDNDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEES 87
            |.|...|.:|:.:.|    ||..|.:::|  |.:..::.|               ..||......
  Fly   162 AVASSIQARLNWNKD----PCTEFKKFSC--WRNTPNKNI---------------TNLIEMGNSQ 205

  Fly    88 SSTDS----FSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPLLANHTGGSFDWV 148
            .|.||    ...|..:..|...|..|:..||..    .|.:..:.|              .||.:
  Fly   206 KSVDSQMLYLFQNKIMNGSFGILHNLFESCLQQ----TTNSTVMHR--------------IFDSL 252

  Fly   149 LANAALRTYGAQGLWRLLVKDNWQSADQRIFYMLP-PKFDLLGRDDELNEFLYQRYLKILLLELG 212
            .....:.:.|...:..|:.|         |:.:.| |..||      .::..|.|...|||:..|
  Fly   253 GGYLPVGSVGPSSIAPLIAK---------IYDLGPSPLVDL------YHDLSYGRRPHILLIISG 302

  Fly   213 LRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLVLRKPQSLKDL-ESQLPRLELKRYF-------- 268
            .......|        |:.::.:.|......:....|:.|.|| |:.||      ||
  Fly   303 PSTSSTIL--------ERKIRWMSPKAPPSRIRQGVPKLLADLIENFLP------YFVSYAQRVS 353

  Fly   269 --ETILEGID--------------WDSKTLLLVADLDYLQGLQR---LLAEHTSDPMVLSTWLLL 314
              :||.|.|.              |||..|..|:.|..|..:..   |:.::.|.|:|:.....|
  Fly   354 EKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLIPQNWSGPIVVRNSDYL 418

  Fly   315 QLPAYFELR-----LHDDDKLGNQRNHCLEQLRKLMPG----------QLGRLQMQLVLGE-SYQ 363
            :...||..:     .|:...|.:    .|:.|.:..|.          .|..|...|.:.: |.:
  Fly   419 KALEYFLTKYPTRVAHNSLLLLS----ALQILPRDYPSPEVCTRSTMWALPELSSSLYIAQHSSE 479

  Fly   364 DVYDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRL-------------LT 415
            |:.||. ::..::|:.||...:...:          .:..|..||.|:::             |.
  Fly   480 DLKDTT-KRAEIIFKSLKAHLKRAPS----------LKGAALVKLSALKIQSQTWEGFSNTTDLL 533

  Fly   416 PRLQDPINGGPGTPQLGGNC-DANLLQLSLSQAKLEYRQV---------FGEPVTSVPADPLSVN 470
            ..|| |:|       :...| ..|:|:: ..:.|||...:         :..|:.|        .
  Fly   534 KSLQ-PLN-------ITSECWFQNILEI-YKKNKLEPNDISLNGGSHDAWAYPIVS--------T 581

  Fly   471 AYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLS-----AGLGYILAHEMVH----AFDLDG 526
            .:|....:.|.:||.::..|..          .|.|.     |.:|..:|.|::.    :||...
  Fly   582 IFYDTLSHSIVVPLSVILIPYF----------NAVLPPYLHYASVGVSIAKEILRSITKSFDEKA 636

  Fly   527 LNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYS-NATLTVN---ENIADTEGLRLALDTYRHR 587
            :............:|...|:   :.:|   |::.| ::.|::.   :.:|...||.|
  Fly   637 MRCVPHSVNIFSNYSRMDIL---IHSG---GMQISYHSMLSLTGPIKGMARLPGLNL-------- 687

  Fly   588 SGATNLRTFFVAFAQNWCGTVASTSGLSQHAG---HAERVNNVVGNMPEFG----DTFECKATSQ 645
               |..:.||:..||..|..       |.:.|   :|...:|::|.:...|    :.|:|.:.|.
  Fly   688 ---TPTQIFFLVSAQELCAE-------SNYLGIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSM 742

  Fly   646 MNPVNKCHI 654
            :|....|::
  Fly   743 INVQKTCNV 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	138/712 (19%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	136/704 (19%)
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	137/706 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910