DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nepl14

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	177/753 - (23%)
Similarity:	290/753 - (38%)	Gaps:	184/753 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPPLSSITRLVVILGVMLLKLAAAQDCQQQLDNDTDAEVKPCENFHQYACGNWYSN-TSQRILG 64
            :.||...|.:     ....::.:.|||....::...|    ||.:|:.||||||.|. |.|:.|.
  Fly    30 LPPPFQRIYQ-----SEQTVRRSKAQDMGSHVNKSID----PCVDFYAYACGNWKSTLTPQQQLQ 85

  Fly    65 AHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCL-----LSGQSIRTYT 124
            ....|         :|:..:||:...:.     ||....|:  .|::.|:     .|.|.....:
  Fly    86 QQTDR---------ELLLLVEEAVRRED-----SVIVRQAK--ELFKSCVSAQAHQSQQQQHFLS 134

  Fly   125 DALSRSGANFPLL------ANHTGGSFDW--VLANAALRTYGAQGLWRLLVKDNWQSADQRIFYM 181
            :.::::| .||.:      .:|  ..::|  ||....|| ||...|..|.|..|:.:.::...|:
  Fly   135 EFINQNG-GFPAVPGSQWAVHH--HDYNWLSVLGGLRLR-YGMDILIGLRVGYNYGNVNENSLYL 195

  Fly   182 LPPK----FDLLGRD-----DELNEFLYQRYLKILLLELGLRVRRAALLAEKLVAFEKSLQKLLP 237
            ..|.    .:|..|:     |.:.|.|..|....|...|.|....:|.||..:::||..|...:.
  Fly   196 SEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDESARLAADILSFEHELCGGMK 260

  Fly   238 N------DAEQTLVL----RKPQSLKDLESQLPRLELKRYFETILEGIDWDSKTLLLVADLDYLQ 292
            .      |||:.|.|    ||  :|::..:.: .|:|..|   :......|....:.:|..:|.:
  Fly   261 GGSFESWDAEEQLYLANYTRK--TLREFSNSI-ELDLDSY---VRASFGQDIYKPVYMAAPEYFR 319

  Fly   293 GLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLV 357
            .|:|.::.|...  :::.:::.:..:.....|.|..:|  ::..|||:.::|:|         ..
  Fly   320 QLKRTVSAHNIS--LVANYIMYRAVSALNFPLDDRPQL--RKRECLERTKELLP---------TA 371

  Fly   358 LGESYQDVYDTAIQQIAV--LFRDLKQQFELVLNETEVFNEDLV--TRNLARDKLRAMRLLTPRL 418
            |||.|...:.|...:|.:  |:..||......|..     |.||  |:.:.::|||.::|..|..
  Fly   372 LGELYARQFGTEDGRIDLDNLYDTLKTALRQSLGA-----EWLVEGTQRVGQEKLRNLKLQMPTY 431

  Fly   419 QDPINGGPGTPQLGGNCDANLLQLSLSQAKL--EYRQVFG-----------EPVTSVPADPLSVN 470
            :.|:                :|:|.|.:...  ..||:.|           |.....|.||  |.
  Fly   432 ERPV----------------ILKLQLERGNYWQNLRQLLGVVQSQRNNRLFEEFLPAPTDP--VE 478

  Fly   471 AY-YRLKL----NRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYD 530
            || .|::|    .|:::.|.|:..|....:..     .|...|.||..||.::|.|||      |
  Fly   479 AYEARVRLRPVQRRLDMGLALLQPPAYDPRYG-----HAIRYATLGVQLAQQLVMAFD------D 532

  Fly   531 ---ATGQLANGQWSARAIIRFGLRAGC-------YLGVRYSNATLTVNENIADTEGLRLALDTYR 585
               :.|.|....|..:...::.:|:.|       ||....|..|    :.|.|:..:.:|...|.
  Fly   533 PHWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYLRPNVSATT----QLITDSAAINVAFRAYL 593

  Fly   586 HRSG--------------------ATNLRTFFVAFAQNWC-----------GTVAS--TSGLSQH 617
            ...|                    .:|...||:|:||..|           ||...  .|....|
  Fly   594 TWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSARQNH 658

  Fly   618 AGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            ......||..:.|..||...|.|...|.|||.:||.|:
  Fly   659 TWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	170/717 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	168/710 (24%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	168/713 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850