DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nepl13

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	170/759 - (22%)
Similarity:	276/759 - (36%)	Gaps:	190/759 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLKLAAAQDCQQQLDNDTDAEVKPCENFHQYACGNW--YS---------NTSQRILGAHDMRSKW 72
            |::...|.|.|:.::...|    ||.:|.:||||.|  |.         :|:|::     |.:|.
  Fly    51 LVRQKIATDVQKYMNLSAD----PCTDFFEYACGQWGRYHKRQLRPDELSTAQQL-----METKI 106

  Fly    73 VANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLL----SGQSIRTYTDALSRSGAN 133
            ...|:..|.:.|......:.:|.  :..|:..::...|..|:.    :.:..|.....|..:|.
  Fly   107 SEQLQQLLTQPLPPQHHPNGYSG--ASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGG- 168

  Fly   134 FPLLANHTGGSF----DWVLANAAL-RTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRD- 192
               |.|....::    .||.....| |.||...|..|.:..|.|:......|...||..::..:
  Fly   169 ---LRNVPNSNWQHNRQWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEH 230

  Fly   193 ------------DELNEFLYQRYLKILLLELGLRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLV 245
                        ||:.|.:.|:..:.|....|:....||..|..::.||..|.|.:   .||.
  Fly   231 CNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQM---GEQD-- 290

  Fly   246 LRKPQ------------------------------SLKDLESQL-PRLELKRYFETILEGIDWDS 279
            ::||:                              :|.:|.|:: ..|:.|...|.|||. .:.|
  Fly   291 IQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILES-QYPS 354

  Fly   280 KTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLRKL 344
            :..|  ...:|::.:.|.:  ..::.:.:..::|  ..|..||....::....:...|::..::|
  Fly   355 QVYL--RSPEYVKHVVRTV--KANNRITVGGYIL--YVALNELNQPPEEAPSQRARQCVQVTQRL 413

  Fly   345 MPGQLGRLQMQLVLGESYQD--VYDTAIQQIAVLFRD----LKQQFELVLNETEVFNEDLVTRNL 403
            .|         .||||.:|.  ..|.|...:..:|.|    |::||.:     |..:|:  .|..
  Fly   414 FP---------QVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFHV-----EWMDEN--DRRA 462

  Fly   404 ARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSLS-------QAKLEYR--------- 452
            ||.:|...|:..|..|              :.|...||...|       :..|:||
  Fly   463 ARTRLSQYRVSLPDYQ--------------SLDLTDLQFQKSEDYWRRLEIALKYRSHQQFEALR 513

  Fly   453 -QVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAH 516
             ..||:....:  |...|.|....:...:.:..||:..|.......|...     .|.||:.||.
  Fly   514 GNDFGQDADGL--DAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLK-----YALLGHRLAS 571

  Fly   517 EMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGC----YLGVRYS------NATLTVNENI 571
            .:|.|||.:|.|   ....|..||:...:..:...:.|    |....|:      ||| .:.|.|
  Fly   572 ALVQAFDDEGWN---NHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNAT-RLREII 632

  Fly   572 ADTEGLRLALDTY-------RHR------------SGATNLRTFFVAFAQNWC------GTVAST 611
            ||..||.||.:.|       .|:            ...||.:.||:.|||..|      ..:..:
  Fly   633 ADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDS 697

  Fly   612 SGLSQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            ..|.||......||..:.|..|||..|.|...:.||..:||.::
  Fly   698 MPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	166/741 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	164/734 (22%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	162/736 (22%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	164/737 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850