DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep6 and phex

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	776	Identity:	172/776 - (22%)
Similarity:	285/776 - (36%)	Gaps:	186/776 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVVILGVMLLKLAAAQDCQQQLDND------------------TDAEVKPCENFHQYACGNWY-- 55
            |.|.:.|.:..|.|.....|:..|:                  .|..|.||::|:|||||.|.
Zfish    25 LAVCVCVCIALLIAVITVSQKASNEDLCLGPHCVEAAGSILSKMDQSVDPCDDFYQYACGGWLRE 89

  Fly    56 -----SNTSQRILGAHDMRSKWV-ANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCL 114
                 .::|..|.       .|: .|:.|:|...||:...:....|       ..:...||..|:
Zfish    90 NPIPEDSSSYGIY-------PWLRQNVDLKLKELLEQPVRSGDIEA-------VKKAKVLYASCM 140

  Fly   115 LSGQSIRTYTDA------LSRSGANFPLLANHTGGSFDWVLAN-------AALRTYGAQG-LWRL 165
              .:|.....||      |.:....:|:|.:..|.|..||.:.       |.:|:..::. |.||
Zfish   141 --NESALEIEDANPLLKNLKQKEFRWPVLGDALGSSSRWVESQFNLLETLAQIRSQHSKSVLIRL 203

  Fly   166 LVKDNWQSADQRIFYMLPPKFDLLGRDDEL-NEFLYQRYLKILL-------LELGLRVRRAALLA 222
            .|..:.::::|.|..:......|..|:|.: |....|.|.:.||       :.||...:.|....
Zfish   204 FVAPDDKNSNQYIIKLDQASLSLSSREDYITNTTEAQMYREALLRLMVDVSVMLGASEQAAEAQM 268

  Fly   223 EKLVAFEKSL-QKLLPNDAEQTLVLRKPQSLKDLESQLPRLELKRYFETILE-----GIDWDSKT 281
            :.::.||..| |.::|.:...:..:....||..|:..:|......:...:::     .:...|..
Zfish   269 KSVLDFEMKLAQIVIPYENRTSENMYNKYSLSKLQRTVPDFNWLGFVRAVIDTELYPDLKISSSE 333

  Fly   282 LLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQ--------LPAYFELRLHD-------DDKLG 331
            .::|....|.:.|.:|:  :.:|...::.:::.:        |...|..|..|       ...|.
Zfish   334 QVIVRAPQYFKDLFKLI--NATDTRTVANYVIWRSVFSRITTLSRRFLYRYLDFARVTTGTTSLT 396

  Fly   332 NQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNE 396
            .:.:.|:..:...:....|||.:.....|..:.:.:..|..|...|.|:.::      |.|..:|
Zfish   397 PRWDKCVNYVENTLIYAAGRLFVDKHFQEDKKHMMEELINGIRWAFIDILEK------ENEWMDE 455

  Fly   397 DLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGG----------NCDANLLQLSLSQAKLEY 451
            :  |:..|.||..|:                .|::|.          |.|...|..:::    :|
Zfish   456 E--TKRKAIDKAHAV----------------LPKVGYPDFILNDTYINEDIKRLAFTMT----DY 498

  Fly   452 RQVFGE--------------------PVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQC 496
               ||.                    |.|....:|.:|||:|....|:|..|.|.:..|...
Zfish   499 ---FGNVMQTLKFIAQSDIGWLRKTVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFW--- 557

  Fly   497 SKEADTRAKLSAG-LGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGC----YL 556
              ..:....||.| :|.|:.||:.|.||.:|..||..|.| :..||..:|.||..:..|    |.
Zfish   558 --GLNYPRSLSYGAIGVIVGHELTHGFDNNGRKYDKDGNL-DQWWSNSSINRFTEKTQCMIDQYN 619

  Fly   557 GVRYSNATL------TVNENIADTEGLRLALDTYR-----HRSGA----------TNLRTFFVAF 600
            ...:..|.|      |:.|||||..|:|.:...||     .|.|.          |:.:.||:::
Zfish   620 SYYWKEAGLNVKGKRTLAENIADNGGIRESFRAYRRWVEKERGGVEEPLLPGVGLTHNQLFFLSY 684

  Fly   601 AQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMN-PVNKCHIW 655
            |...|......:...|     |:....||...:.|..||...|.|..||.|| ....|.:|
Zfish   685 AHVRCNAYRPEAARDQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMNRGAESCRVW 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	164/750 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	162/725 (22%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	164/737 (22%)
phex	NP_001307259.1	M13	72..743	CDD:189000	162/725 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920