DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and KEL

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	762	Identity:	162/762 - (21%)
Similarity:	274/762 - (35%)	Gaps:	199/762 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVILGVML---------LKLAAAQDCQQQLDNDT--------DAEVKPCENFHQYACGN-WYSNT 58
            ::|||::|         .:....:.|:..:..|.        :..|.||.:|..:|||. ..:|.
Human    64 ILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNN 128

  Fly    59 SQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTY 123
            |.:.|...:         |.:|.|.||..:|....|......       ..|..|:        .
Human   129 SFQELATKN---------KNRLRRILEVQNSWHPGSGEEKAF-------QFYNSCM--------D 169

  Fly   124 TDALSRSGANFPL--LANHTGG---SFDWVLAN------AALRTYGAQGLWRLLVKDNWQSADQR 177
            |.|:..:|.. ||  :....||   |..|...|      ..:..||....:|..:..:..|....
Human   170 TLAIEAAGTG-PLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTP 233

  Fly   178 IFYMLPPKFDL-LGRDDELNEF--LYQRYLKILLLELGL-------RVRRAALLAEKLVAFEKSL 232
            :..:..|:||: |.:|.|...:  :::.|| ..|.:||.       :|:..:.|:..:.:  :..
Human   234 VIQIDQPEFDVPLKQDQEQKIYAQIFREYL-TYLNQLGTLLGGDPSKVQEHSSLSISITS--RLF 295

  Fly   233 QKLLPNDAEQTLVLRKPQ-------SLKDLESQLPRLELKRYFETILEGIDWDSKTLLLVADLDY 290
            |.|.|      |..|:.|       ::..|:...|.::.....:.....:.......|:|.|::|
Human   296 QFLRP------LEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEY 354

  Fly   291 LQGLQRLLAE-------HTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLRKL---- 344
            |:.:.:|:.|       .....|:|...:.|. ||.       |.:....|....::||:|
Human   355 LKNMSQLVEEMLLKQRDFLQSHMILGLVVTLS-PAL-------DSQFQEARRKLSQKLRELTEQP 411

  Fly   345 -MPGQLGRLQMQLVLGESYQ---------DVYDTAIQQIAV-LFRDLKQQFELVLNETEVFNEDL 398
             ||.:...::.....|..::         :.:..:.:..|: ||..::......|......||:
Human   412 PMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEE- 475

  Fly   399 VTRNLARDKLRAMRL--------LTPRL-QDPINGGPGTPQLGGNCDANLLQLSLS-----QAKL 449
             |:|:|:||:..:::        |.|.| :...|    ..|||    ::.||..||     :|::
Human   476 -TQNMAQDKVAQLQVEMGASEWALKPELARQEYN----DIQLG----SSFLQSVLSCVRSLRARI 531

  Fly   450 EYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYIL 514
            ....:...|.......|..|||||.:..:.:..|.||:..|...     ....||......|.|:
Human   532 VQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFH-----PGYPRAVNFGAAGSIM 591

  Fly   515 AHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCY----------------------LG 557
            |||::|.|                       .:..|..||.                      |.
Human   592 AHELLHIF-----------------------YQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLP 633

  Fly   558 VRYS-NATLTVNENIADTEGLRLALDTY-----RHRSGATNL--------RTFFVAFAQNWCGTV 608
            .|.| |.:||..||.||..||.:||..|     ||. |.|.|        :.||.::||..|...
Human   634 SRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHH-GETVLPSLDLSPQQIFFRSYAQVMCRKP 697

  Fly   609 ASTSGLSQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            :.......|:....||:..:.:.|.|...|.|...:.:||.::|.:|
Human   698 SPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	156/728 (21%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	154/713 (22%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	155/718 (22%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	154/713 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810