DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nepl7

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	182/729 - (24%)
Similarity:	290/729 - (39%)	Gaps:	146/729 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSSITRLVVILGVMLLKLAAAQDCQQQLDND--------TDAEVKPCENFHQYACGNWYS----- 56
            |.|:|.:..:|...|..|..|.:.::::..|        .:..:.|||||::::||.|..
  Fly     9 LISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKKADLVP 73

  Fly    57 ----NTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTST-AQLGTLYRCCLLS 116
                |||  .|.|...:      :..|:..:|:.::..:......:.|||. .:....|..|:
  Fly    74 EQARNTS--FLNAIQHK------IDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCV-- 128

  Fly   117 GQSIRTYTDALSRSGANFPLLANHTG-------GSFDWVLANAALRTYGAQGLWRLLVKDNWQSA 174
                    :..:.....:.....|.|       .::||:..| .:..|....|..|.|..:..|.
  Fly   129 --------EMKANLSLGYQYFMEHDGDRLKERNATYDWMYIN-FMSKYDIYPLLALKVHYSTSSR 184

  Fly   175 DQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILLLELGL-----RVRRAALLAEKLVAFEKSLQK 234
            ...|...||.|. |.|..:|        .||.:..|.||     :|::.......|..||::|..
  Fly   185 KFDILLTLPSKV-LAGFSEE--------QLKNMTREFGLDSSAEKVKQFVENFNNLTQFERNLVS 240

  Fly   235 LLP--NDAEQTLVLRKPQSLKD--LESQLPRLELKRYFETILEGID---WDSKTLLLVADLDYLQ 292
            |..  |:.||.       :.|:  ::.:..||...|:||....|..   |.     ::..||.:.
  Fly   241 LAKSRNETEQL-------NFKEFLVKHKHDRLNWTRFFELAFNGSQESHWP-----VLNQLDNIN 293

  Fly   293 GLQRLLAEHTSDPMVLSTWLLLQLPAYFELR--------LHDDDKLGNQRNHCLEQLRKLMPGQL 349
            .|...| |.|:         |..|..|.::|        .....|.|..::.|    |.|.....
  Fly   294 DLVFFL-EQTN---------LETLKGYIKMRELVKFYGLWKTQTKTGGVQSEC----RSLSETYF 344

  Fly   350 GRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLL 414
            ....:...:|:.:.......|..:|   :|:|..|..:|:.....:||  ||:.|:.||.:|.:|
  Fly   345 NYALLPWFIGKVFDKERRADILSVA---KDIKDTFYDLLDHHTWLDED--TRSQAKTKLASMDIL 404

  Fly   415 ---TPRLQ--DPINGGPGTPQLGGNCDANLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAYYR 474
               |..||  :.|:|......:.||...||..|..|:|::..|.| .:.:..:.....:|||||.
  Fly   405 VGYTDDLQHREVIDGVYSDINMTGNWFENLCILEGSRARIRLRSV-DKALIPLLMPTRTVNAYYA 468

  Fly   475 LKLNRIELPLGLMATPLIQQQCSKEADTRAKLS-AGLGYILAHEMVHAFDLDGLNYDATGQLANG 538
            ..||...:.:|:...|..      ..|....|. ||:|.|:.|||.|.||.....|:..|:..|
  Fly   469 DFLNLAFITIGMAQWPFY------HIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTN- 526

  Fly   539 QWSARAIIRFGLRAGC---------YLGVRYSNATLTVNENIADTEGLRLALDTYRHRSG----- 589
            .||:.::..|..|..|         .:||: :|.:||..:||||..|.|:|...::.::|
  Fly   527 WWSSASLRNFKERYRCLESQYNKFILMGVQ-TNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWL 590

  Fly   590 --------ATNLRTFFVAFAQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECK 641
                    ..|.:.|||.|||.||....:...|.:     ||....||...:.|||||.:.|.||
  Fly   591 EKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCK 655

  Fly   642 ATSQMNPVNKCHIW 655
            ..::|||:.||.:|
  Fly   656 LGTEMNPLKKCVVW 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	174/697 (25%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	172/682 (25%)
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	173/693 (25%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	171/681 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0006719
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850