DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Nep1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	175/735 - (23%)
Similarity:	284/735 - (38%)	Gaps:	158/735 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LAAAQDCQQ---QLDNDTDAEVKPCENFHQYACGNW------------------YSNTSQRILGA 65
            :...|:|.:   .|.:..|....|||:|.|||||.|                  .|:..|.||.|
  Fly   172 ICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRA 236

  Fly    66 HDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDALS-- 128
                             .|||........|       |.:..|.::.|:...|..:..|..|.
  Fly   237 -----------------VLEEPIDERDNKA-------TIKAKTFFKSCMDIPQIRKIGTGRLKQV 277

  Fly   129 -RSGANFPLLANHTGGSFDWVLAN--AALR-TYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLL 189
             :|...:|::..:.....|..:..  ..|| .|....:..|.|..:.:::...|..|...::.|.
  Fly   278 LQSLGGWPVIERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALP 342

  Fly   190 GRDDELNEF------LYQRYLKILLLELGLRVRRAALLAEKLVAFEKSLQKL-LPN-DAEQTLVL 246
            .||..|.|.      .|.||:..:.|.||.....||...||:|.||..|..: ||. |...|.::
  Fly   343 SRDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLV 407

  Fly   247 RKPQSLKDLESQLPRLELKRYFETIL-EGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLST 310
            .:...|.:|:..:|.::.:.|.:..| .||.......|:...|.||..:.::|| || |..|:..
  Fly   408 YRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILA-HT-DRRVVHN 470

  Fly   311 WLLLQLPAYFELRLHDDDKLGNQR-----------------NHCLEQLRKLMPGQLGRLQMQLVL 358
            ::|.:|  ...|..|..|:...:|                 :.|:|...|.:...:|.|.:
  Fly   471 YMLWRL--VMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFI---- 529

  Fly   359 GESYQDVYDTAIQQIAV-LFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPI 422
                :|.::...:::|: :...::..|..:|.|.:..:::  ||.:|::|           .|.:
  Fly   530 ----RDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDE--TRAVAKEK-----------ADSM 577

  Fly   423 NGGPGTPQLGGNCD------ANLL---------QLSLSQAKLE-YRQVFGEPVTSV--PADPLSV 469
            |...|.|:|..|..      .||.         .||:.|.:.| ..::..:||...  ..:|..|
  Fly   578 NERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVV 642

  Fly   470 NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQ 534
            ||:|....|.|..|.|::......|...|..:     ..|:|.::.||:.|.||..|..:|..|.
  Fly   643 NAFYNPNKNDIVFPAGILQPLFYSQHFPKSLN-----YGGIGVVIGHEITHGFDDKGRQFDKEGN 702

  Fly   535 LANGQWSARAIIR-FGLRAGCYLGVRYS-----------NATLTVNENIADTEGLRLALDTYRHR 587
            :.  ||...|.|. |..|..|.:. :||           :..:|..|||||..||:.|...|:..
  Fly   703 MM--QWWNNATIEAFRERTQCVID-QYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKW 764

  Fly   588 S------------GATNLRTFFVAFAQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFG 635
            .            ..|:.:.||:.:||.|||::.....|::     |:....||...:.|..:|.
  Fly   765 ETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFA 829

  Fly   636 DTFECKATSQMNPVNKCHIW 655
            ..::|...|.|||..||.:|
  Fly   830 SAYKCPLGSTMNPAEKCSVW 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	171/717 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	169/710 (24%)
Nep1	NP_001284925.1	M13	194..847	CDD:189000	169/709 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850