DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Mmel1

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	177/783 - (22%)
Similarity:	285/783 - (36%)	Gaps:	249/783 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LAAAQDCQQQLDNDTDAEVKPCENFHQYACGNWYSN-----TSQRILGAHDMRSKWVANLKLQLI 81
            :|||:..|     :.|...|||:||:|||||.|..:     |:.|......:|.:    |::.|.
  Rat    92 IAAARILQ-----NMDQSKKPCDNFYQYACGGWLRHHVIPETNSRYSVFDILRDE----LEVILK 147

  Fly    82 RYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDA------LSRSGANFPLLA-- 138
            ..||:||        .....:..:..||||.|:  .||:....|:      |...| .:|:..
  Rat   148 GVLEDSS--------VQHRPAVEKAKTLYRSCM--NQSVIEKRDSEPLLNVLDMIG-GWPVAMDK 201

  Fly   139 -NHTGGSFDWVLAN--AALRT-YGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFL 199
             |.|.|. .|.|..  |.|.: :..:.|..|.:.::.|::.:.:.|:..|...:..|
  Rat   202 WNETMGP-KWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSR-------- 257

  Fly   200 YQRYLKILLLELGLRVRRAALLAEKLVAFEKSLQKLLPND----AEQTLVLRKPQSLKDLESQLP 260
             :.|.|    |...|||.|.|      .|..|:..:|..|    .|..||..:...:..||:.|.
  Rat   258 -EYYFK----EDSHRVREAYL------QFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHLA 311

  Fly   261 -----------------RLELKRYFETI-LEGIDWDSKTL------------------LLVADLD 289
                             |:.|:...|.. |:|.:|   ||                  ::|..:.
  Rat   312 NATVPQEKRHDVTALYHRMGLEELQERFGLKGFNW---TLFIQNVLSSVQVELLPNEEVVVYGIP 373

  Fly   290 YLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKLG--NQR------------------ 334
            ||:.|:.::  .......|..:|:.:|..         |::|  :||
  Rat   374 YLENLEEII--DVFPAQTLQNYLVWRLVL---------DRIGSLSQRFKEARVDYRKALYGTTME 427

  Fly   335 ----NHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRD------------LKQQ 383
                ..|:..:...|...:|.|.::....:..:.:....|::|..:|.|            .|:.
  Rat   428 EVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNLDELNWMDEESKKKA 492

  Fly   384 FELVLNETE-----------------------VFNEDLV----TRNLARDKLRAMRLLTPRLQDP 421
            .|..||..|                       .|:|||.    .:||..:..|:::.|..::
  Rat   493 QEKALNIREQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKV--- 554

  Fly   422 INGGPGTPQLGGNCDANLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGL 486
                          |.||             .:.|..|         |||:|....|.|..|.|:
  Rat   555 --------------DQNL-------------WIIGAAV---------VNAFYSPNRNLIVFPAGI 583

  Fly   487 MATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLR 551
            :..|..    ||: ..:|....|:|.::.||:.|.||.:|.|:|..|.:.: .||..:...|..:
  Rat   584 LQPPFF----SKD-QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLD-WWSNFSARHFRQQ 642

  Fly   552 AGCYLGVRYSNAT------------LTVNENIADTEGLRLALDTY---------RHRSGATNL-- 593
            :.|.: .:|||.:            .|:.|||||..|:|.|...|         ..|....||
  Rat   643 SQCMI-YQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQRLPGLNLTY 706

  Fly   594 -RTFFVAFAQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKC 652
             :.||:.:||.|||:......:..     |:....||...:.|:|.|.:.|.|...|.|:|:|:|
  Rat   707 AQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMNRC 771

  Fly   653 HIW 655
            .||
  Rat   772 RIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	171/768 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	169/761 (22%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	169/760 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920