DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Phex

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	171/773 - (22%)
Similarity:	295/773 - (38%)	Gaps:	184/773 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VILGVM-------LLKLAAAQ------DCQQ---QLDNDTDAEVKPCENFHQYACGNWYSNTSQR 61
            ::||.:       ||...|.|      :|.:   .:.:..:..|.|||||.::||..|.||...
  Rat    31 LVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPI- 94

  Fly    62 ILGAHDMRS----KWVA-NLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIR 121
               ..||.|    .|:. |:.|:|...||:|.|      ....|.:..:...||..|:
  Rat    95 ---PEDMPSYGVYPWLRHNVDLKLKALLEKSVS------RRRDTEAVQKAKILYSSCM------- 143

  Fly   122 TYTDALSRSGANFPLLANHTGGSFDWVLANAALRTYGAQGLW----------------------- 163
             ...|:.::.|. |||.......|.|.:..|.:   |.:|:|
  Rat   144 -NEKAIEKADAK-PLLHILRHSPFRWPVLEANI---GPEGVWSERKFSLLQTLATFRGQYSNSVF 203

  Fly   164 -RLLVKDNWQSADQRIFYMLPPKFDLLGRDDELN---------EFLYQRYLKILLLELGLRVRRA 218
             ||.|..:.:::::.|..:......|..|:|.|:         :.||:..:...:| ||....||
  Rat   204 IRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVL-LGANSSRA 267

  Fly   219 ALLAEKLVAFE-KSLQKLLPNDAEQTLVLRKPQSLKDLESQLPRLELKRYFETILEGIDWDSKTL 282
            ....:.::..| |..:.::|::...:..:....::.:|.:.:|:.:...|.:.::     |::..
  Rat   268 EHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVI-----DTRLY 327

  Fly   283 LLVADL-----------DYLQGLQRLL-AEHTSDPMVLSTWLLL-----QLPAYFELR------- 323
            ..:.|:           .|.:.|.|:| ||..........|.::     .|...|:.|
  Rat   328 PHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRV 392

  Fly   324 LHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVL 388
            :.....|..|.:.|:..:...:|..:|::.:.:...|..:::.:..|:.:...|.|:.::
  Rat   393 IQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEK----- 452

  Fly   389 NETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGN---CDANLLQLSLSQAK-- 448
             |.|..  |..|:..|::|.||           :....|.|:...|   .:.:|..:..|::.
  Rat   453 -ENEWM--DAGTKRKAQEKARA-----------VLAKVGYPEFIMNDTYVNEDLKAIKFSESDYF 503

  Fly   449 ---LEYRQVFGE----------PVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEA 500
               |:.|:...:          |.|....:|.:|||:|....|:|..|.|.:..|...     ..
  Rat   504 GNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFW-----GT 563

  Fly   501 DTRAKLSAG-LGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSN-- 562
            :....||.| :|.|:.||..|.||.:|..||..|.| :..||..:..:|..:..|.:. :|||
  Rat   564 EYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNL-DPWWSVDSEEKFKEKTKCMIN-QYSNYY 626

  Fly   563 ---------ATLTVNENIADTEGLRLALDTYR-----HRSGA----------TNLRTFFVAFAQN 603
                     ...|:.|||||..|||.|...||     .|.|.          ||.:.||:::|..
  Rat   627 WKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHV 691

  Fly   604 WCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMN-PVNKCHIW 655
            .|.:....:...|     |:....|||..:.|..||...|.|.|.|.|| ..:.|.:|
  Rat   692 RCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	163/733 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	162/726 (22%)
Phex	NP_037136.2	M13	74..740	CDD:341056	160/719 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920