DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Mme

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	771	Identity:	169/771 - (21%)
Similarity:	304/771 - (39%)	Gaps:	171/771 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSSITRLVVILGVMLLKLAAAQD---CQQ--------QLDNDTDAEVKPCENFHQYACGNWYS-- 56
            ||.:..|:.|:.|.::.|.|..|   |:.        :|..:.||..:||.:|.:||||.|..
  Rat    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRN 95

  Fly    57 ---NTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCL---- 114
               .||.|......:|.:    |::.|...|:|..:.|        ..:..:..||||.|:
  Rat    96 VIPETSSRYSNFDILRDE----LEVILKDVLQEPKTED--------IVAVQKAKTLYRSCINESA 148

  Fly   115 ---LSGQSIRTYTDALSRSGANFPLLANH---TGGSFDWVLANAALR---TYGAQGLWRLLVKDN 170
               ..||.:.|....:    ..:|:.:.:   |.|: .|....:..:   .||.:.|....|..:
  Rat   149 IDSRGGQPLLTLLPDI----YGWPVASQNWEQTYGT-SWTAEKSIAQLNSKYGKKVLINFFVGTD 208

  Fly   171 WQSADQRIFYMLPPKFDLLGRDDELNEFLYQR----YLKILLLELGL-RVRRAALLAEKLVAFEK 230
            .:::.|.|.:...|:..|..||......:|:.    |:..::....| |..:...:.|..::.|
  Rat   209 DKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLE- 272

  Fly   231 SLQKLLPNDAEQTLVLRKPQSLKD---LESQLPRLELKRYFETILEG--IDWDSKTLLLVADL-- 288
             :.|::..:.|......||:...|   |.:::...:|:..|...:.|  ..|.:.|..:::.:
  Rat   273 -MNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNI 336

  Fly   289 -------------DYLQGLQRLLAEHT-SDPMVLSTW-LLLQLPA-----YFELR------LHDD 327
                         :||..|:.:|.::: .|...|.:| .::.|.:     |.|.|      |:..
  Rat   337 NIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGT 401

  Fly   328 DKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLF-----------RDLK 381
            .........|...:...|...:|||.::.......:.|.:..|.||..:|           .:.|
  Rat   402 TSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETK 466

  Fly   382 QQFE---LVLNETEVFNEDLVTRNLARDKLRAMRL-LTPRLQDPINGGPGTPQLGGNCDANLLQ- 441
            ::.|   |.:.|...:.:|:::.   .:||....| |..:.::...              |::|
  Rat   467 KKAEEKALAIKERIGYPDDIISN---ENKLNNEYLELNYKEEEYFE--------------NIIQN 514

  Fly   442 LSLSQAK--LEYRQ-------VFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCS 497
            |..||:|  .:.|:       :.|..|         |||:|....|:|..|.|::..|....:.|
  Rat   515 LKFSQSKQLKKLREKVDKDEWISGAAV---------VNAFYSSGRNQIVFPAGILQPPFFSARQS 570

  Fly   498 KEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYL------ 556
            ...:     ..|:|.::.||:.|.||.:|.|::..|.|.: .|:.::...|..::.|.:
  Rat   571 NSLN-----YGGIGMVIGHEITHGFDDNGRNFNKDGDLVD-WWTQQSANNFKDQSQCMVYQYGNF 629

  Fly   557 -----GVRYSNATLTVNENIADTEGLRLALDTYRH---RSGATNL---------RTFFVAFAQNW 604
                 |.::.|...|:.|||||..|:..|...|::   ::|...|         :.||:.|||.|
  Rat   630 TWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVW 694

  Fly   605 CGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |||......::.     |:....|:...:.|..||.|.|.|:..|.|||..||.:|
  Rat   695 CGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	158/728 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	155/721 (21%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	155/719 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020