DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Kel

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	734	Identity:	168/734 - (22%)
Similarity:	268/734 - (36%)	Gaps:	189/734 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CQQQLDN---DTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSS 89
            |.:.||:   ..:..|.||.:|..:||        ::..|..|.........|.:|.|.||...|
Mouse    63 CMELLDHYLASGNRSVAPCTDFFSFAC--------EKANGTSDSFQALTEENKSRLWRLLEAPGS 119

  Fly    90 TDSFSANTSVTTSTAQLGT-------LYRCCLLSGQSIRTYTDALSRSGANFPLLA--------N 139
            .              .||:       .|..|:        .|||:..||:. ||:.        |
Mouse   120 W--------------HLGSGEEKAFQFYNSCM--------DTDAIEASGSG-PLIQIIEELGGWN 161

  Fly   140 HTGG--SFDWVLANAALR----TYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDE---- 194
            .||.  |.|:   |..||    .||....:|..::.:.......|..:..|:||:|.:.::
Mouse   162 ITGNWTSLDF---NQNLRLLMSQYGHFPFFRAYLRPHPAPPHTPIIQIDQPEFDILLQQEQEQKV 223

  Fly   195 ----LNEFLYQRYLKILLLELGLRVRRAALLAEKLVAFEKSL-QKLLPNDAEQTL-VLRKPQSLK 253
                |.|  |..||..|...||...:.|...|...:.|...| |.|.|...:|.. .|....::.
Mouse   224 YAQILRE--YVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTID 286

  Fly   254 DLESQLPRLELKRYFETILEGIDWDSKTLLLVADLDYLQGLQRLLAE----HTSDPMVLSTWLLL 314
            :|:...|.::.....:.|...:..:|...|:|.|||||:.:.:|:.|    |...   :.::::|
Mouse   287 ELQEMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQLVEEGLLNHRES---IQSYMIL 348

  Fly   315 QL-----PAYFELRLHDDDKLGNQRNHCLEQLRKL-----MPG---------QLGRLQMQLVLGE 360
            .|     ||.       |.|....|...:::||||     :|.         |.|......:...
Mouse   349 GLVDTLSPAL-------DTKFQEARRELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAAL 406

  Fly   361 SYQDVYDTAIQQIAV-LFRDLKQQFELVLNETEVFNEDLVTRNLARDKL-----------RAMR- 412
            ..::.:..:||..|: ||.::|....:.|.:....:|:  |:..|.:||           ||::
Mouse   407 FVREAFGPSIQSAAMELFAEIKDAVIIRLKKLSWISEE--TQKEALNKLAQLQVEMGAPKRAVKP 469

  Fly   413 -LLTPRLQDPINGGPGTPQLGGNCDANLLQLSLSQAKLEYRQVFGEPVTSVPADPLSVNAYYRLK 476
             :.|....| |..||...|...:|..:|...::.    .:.|.|  |.......|..|||||.:.
Mouse   470 DIATQEYND-IQLGPSFLQSFLSCVRSLRARNVQ----SFLQPF--PYHRWQKSPWEVNAYYSIS 527

  Fly   477 LNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWS 541
            .:.:..|.||:..|...     ....||......|.|:|||::|.|
Mouse   528 DHMVVFPAGLLQPPFFH-----PGYPRAVNFGAAGSIMAHELLHIF------------------- 568

  Fly   542 ARAIIRFGLRAGC-------------YLGVRYS----------NATLTVNENIADTEGLRLALDT 583
                .:..|..||             .|...|:          |.:.|:.||.||..|:.:|...
Mouse   569 ----YQLLLPGGCPACDTHVLQEALLCLERHYAAFPLPSISSFNGSHTLLENAADIGGVAIAFQA 629

  Fly   584 YRHR----SGATNL--------RTFFVAFAQNWCGTVASTSGLSQHAGHAERVNNVVGNMPEFGD 636
            |..|    :|...|        :.||.::||..|..::|......|:..:.||:..:.|.|:|..
Mouse   630 YSKRIVEHTGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQDPQDPHSPPSLRVHGPLSNTPDFAK 694

  Fly   637 TFECKATSQMNPVNKCHIW 655
            .|.|...:.:||..:|.:|
Mouse   695 HFHCPRGTLLNPSARCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	164/722 (23%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	163/715 (23%)
Kel	NP_115929.3	M13	78..711	CDD:341056	163/715 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810