Protein Alignment Nep6 and nep-20

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001317749.1
• Gene: nep-20 / 188176
• WormBaseID: WBGene00020293
• Length: 834
• Species: Caenorhabditis elegans
• Alignment Length: 762
• Identity: 152/762 - (19%)
• Similarity: 274/762 - (35%)
• Gaps: 243/762 - (31%)

  Fly    11 LVVILGVMLLKLAAAQD-----CQQ--------QLDNDTDAEVKPCENFHQYACGNWYSNTSQRI 62
            :::||..:||.:.|.||     |:.        :|....|..|..|.||::..||.:   ...:.
 Worm   193 ILIILFWLLLFIGARQDEKPSLCESPQCITLAFELSAYQDTSVSKCHNFYKATCGKY---KHHQA 254

  Fly    63 LGAH-DMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDA 126
            |..| |.:.|.|....::......|||.|..|.         ..:..::..|....|: :||.|.
 Worm   255 LDKHRDAKKKEVVKRIVREFLRRNESSITSKFE---------PAIRLMFGKCNKFSQN-KTYLDI 309

  Fly   127 ---LSRSGANFPLLANHTGGSFDWVLANAALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDL 188
               :.:.|. :|:|.:      |||                                      |:
 Worm   310 FKDIEKIGP-WPVLKS------DWV--------------------------------------DV 329

  Fly   189 LGRDDELNEFLYQRYLKILLLELG--------LRVRRAALLAEKLVA---------FEKSLQKLL 236
            :   ..||::|      :.|:|||        |..|:.|.....::|         .||.:.::|
 Worm   330 M---FNLNDYL------LSLVELGFTDFGLFKLEFRQLAFGQFPVIAPSEQKQGNQLEKIILEIL 385

  Fly   237 PND---AEQTLVLRKPQSLKDLESQLPRLELKRYFETILEGIDWDSKTLLL--------VADLDY 290
            ..:   |::..:.:..:...:.:|||..:.|:   .|.::.|.:::.||.:        :|.:..
 Worm   386 EANGVQADRQKLSKYLREYSEFKSQLRHMSLE---GTSVKYIRYNASTLSVNISALVQKMAPMST 447

  Fly   291 LQGLQR------LLAEHTS------DPMV-------LSTWLLLQLPAYFELRLHDDDKLGNQRNH 336
            ..||.|      |:...:|      |.::       |:.:|:..   :.:....|   |.:...|
 Worm   448 SSGLVRRIQSGILITNSSSFFGKNLDAIIQQTHKRTLANYLIFH---FIDAVTFD---LTSGAKH 506

  Fly   337 CLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQ-FELV-----LNETEVFN 395
            ....|..|:|  .|.||   ||.:.:.|..|..:  :..:.:|||:. .|::     |::..:..
 Worm   507 SEHTLIDLLP--RGSLQ---VLSQDFVDEEDQGV--MVEMAKDLKKHVVEMISEGSSLDKGHLVF 564

  Fly   396 EDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSL---------------- 444
            |:...|.|.| |::.:.::|....:.:|             .|..:|:|
 Worm   565 EEKERRKLIR-KVQDILVVTKYPLEILN-------------QNFEKLNLTYSDSLHKIIQKLRRF 615

  Fly   445 -SQAKLEYRQVFGEPVTSVPADPLSV----NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRA 504
             |:..:||  :.|:      .||...    :|:|....|.:     ::..|:|.   ....||..
 Worm   616 RSEQLIEY--LGGD------LDPTDKGMWGSAHYEQATNDL-----IIIAPIID---GPYFDTSY 664

  Fly   505 KLSAG---LGYILAHEMVHAFDLDGLNYDATGQLANGQW-SARAIIRFGLRAGCY----LGVRYS 561
            .....   :|:|::.|:..:.|...:..|..|...|  | .:.::.||.....|:    .|.|:
 Worm   665 PNYVNIFFMGFIISRELGRSLDSVRIRKDEKGHTEN--WLKSESLKRFDNNVKCWRKKITGTRF- 726

  Fly   562 NATLTVNENIADTEGLR---LALDTYRHRSGATNL------------RTFFVAFAQNWCGTVAST 611
                 :||.:||..|..   :||..:......|.:            :.||...|..:|.....:
 Worm   727 -----LNEMLADHVGHEASFMALKKWEKEMNGTIVEKIRGYESMTMEQIFFHLQALYFCRPPGGS 786

  Fly   612 SG------LSQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKC 652
            :|      ..||  ::.|||....|||:|...|.|.:...||...||
 Worm   787 TGELTAKDARQH--YSTRVNEAFKNMPQFAKAFGCSSNQNMNSKTKC 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	142/720 (20%)
nep-20	NP_001317749.1	PHA02030	<71..139	CDD:222843
		GluZincin	238..832	CDD:472708	141/717 (20%)