DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-20

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001317749.1	Gene:	nep-20 / 188176	WormBaseID:	WBGene00020293	Length:	834	Species:	Caenorhabditis elegans

Alignment Length:	762	Identity:	152/762 - (19%)
Similarity:	274/762 - (35%)	Gaps:	243/762 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVVILGVMLLKLAAAQD-----CQQ--------QLDNDTDAEVKPCENFHQYACGNWYSNTSQRI 62
            :::||..:||.:.|.||     |:.        :|....|..|..|.||::..||.:   ...:.
Worm   193 ILIILFWLLLFIGARQDEKPSLCESPQCITLAFELSAYQDTSVSKCHNFYKATCGKY---KHHQA 254

  Fly    63 LGAH-DMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDA 126
            |..| |.:.|.|....::......|||.|..|.         ..:..::..|....|: :||.|.
Worm   255 LDKHRDAKKKEVVKRIVREFLRRNESSITSKFE---------PAIRLMFGKCNKFSQN-KTYLDI 309

  Fly   127 ---LSRSGANFPLLANHTGGSFDWVLANAALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDL 188
               :.:.|. :|:|.:      |||                                      |:
Worm   310 FKDIEKIGP-WPVLKS------DWV--------------------------------------DV 329

  Fly   189 LGRDDELNEFLYQRYLKILLLELG--------LRVRRAALLAEKLVA---------FEKSLQKLL 236
            :   ..||::|      :.|:|||        |..|:.|.....::|         .||.:.::|
Worm   330 M---FNLNDYL------LSLVELGFTDFGLFKLEFRQLAFGQFPVIAPSEQKQGNQLEKIILEIL 385

  Fly   237 PND---AEQTLVLRKPQSLKDLESQLPRLELKRYFETILEGIDWDSKTLLL--------VADLDY 290
            ..:   |::..:.:..:...:.:|||..:.|:   .|.::.|.:::.||.:        :|.:..
Worm   386 EANGVQADRQKLSKYLREYSEFKSQLRHMSLE---GTSVKYIRYNASTLSVNISALVQKMAPMST 447

  Fly   291 LQGLQR------LLAEHTS------DPMV-------LSTWLLLQLPAYFELRLHDDDKLGNQRNH 336
            ..||.|      |:...:|      |.::       |:.:|:..   :.:....|   |.:...|
Worm   448 SSGLVRRIQSGILITNSSSFFGKNLDAIIQQTHKRTLANYLIFH---FIDAVTFD---LTSGAKH 506

  Fly   337 CLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQ-FELV-----LNETEVFN 395
            ....|..|:|  .|.||   ||.:.:.|..|..:  :..:.:|||:. .|::     |::..:..
Worm   507 SEHTLIDLLP--RGSLQ---VLSQDFVDEEDQGV--MVEMAKDLKKHVVEMISEGSSLDKGHLVF 564

  Fly   396 EDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSL---------------- 444
            |:...|.|.| |::.:.::|....:.:|             .|..:|:|
Worm   565 EEKERRKLIR-KVQDILVVTKYPLEILN-------------QNFEKLNLTYSDSLHKIIQKLRRF 615

  Fly   445 -SQAKLEYRQVFGEPVTSVPADPLSV----NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRA 504
             |:..:||  :.|:      .||...    :|:|....|.:     ::..|:|.   ....||..
Worm   616 RSEQLIEY--LGGD------LDPTDKGMWGSAHYEQATNDL-----IIIAPIID---GPYFDTSY 664

  Fly   505 KLSAG---LGYILAHEMVHAFDLDGLNYDATGQLANGQW-SARAIIRFGLRAGCY----LGVRYS 561
            .....   :|:|::.|:..:.|...:..|..|...|  | .:.::.||.....|:    .|.|:
Worm   665 PNYVNIFFMGFIISRELGRSLDSVRIRKDEKGHTEN--WLKSESLKRFDNNVKCWRKKITGTRF- 726

  Fly   562 NATLTVNENIADTEGLR---LALDTYRHRSGATNL------------RTFFVAFAQNWCGTVAST 611
                 :||.:||..|..   :||..:......|.:            :.||...|..:|.....:
Worm   727 -----LNEMLADHVGHEASFMALKKWEKEMNGTIVEKIRGYESMTMEQIFFHLQALYFCRPPGGS 786

  Fly   612 SG------LSQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKC 652
            :|      ..||  ::.|||....|||:|...|.|.:...||...||
Worm   787 TGELTAKDARQH--YSTRVNEAFKNMPQFAKAFGCSSNQNMNSKTKC 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	143/725 (20%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	142/720 (20%)
nep-20	NP_001317749.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920