Protein Alignment Nep6 and nep-2

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 774
• Identity: 177/774 - (22%)
• Similarity: 308/774 - (39%)
• Gaps: 168/774 - (21%)

  Fly     2 KPPLSSITRL-----VVILGVMLLKLAAA----------------QDCQQQLD---NDTDAEVKP 42
            |.|.|..||:     :::|.:.||.|.||                ..|.:...   :..::.|.|
 Worm    11 KSPGSRWTRIWAIIALILLILFLLVLGAAIYFYINYKDSSDVCLSPGCIKTASVILSSMNSSVDP 75

  Fly    43 CENFHQYACGNW---------------YSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDS 92
            |::|:::|||.|               :.|..|              :|:..|...|:|:.....
 Worm    76 CDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQ--------------DLEFALKELLDENDEPYD 126

  Fly    93 FSANTSVTTSTAQLGTLYRCCLLSGQSI---RTYTDALSRSGANFPLLANH--TGGSFDWVLANA 152
            :.     |::..:....|..||...:.:   ||..|.:.:|...:|.|.:.  ...|.:.:.|:.
 Worm   127 YE-----TSAVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADM 186

  Fly   153 ALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRD-----DELNEFLYQRYLKILLLELG 212
            ..: :.|..|::..|:.:.:::.:.:..:..|:.:|..||     :......|.:.::.:|:.|.
 Worm   187 VAK-FKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLD 250

  Fly   213 LRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLV--LRKPQSLKDLESQLPRLELKRYFETILEG- 274
            ....||.|.|::::.||.:|..:...|..:..:  |....:|.::...||......:|..:.:.
 Worm   251 ADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKDL 315

  Fly   275 -------IDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMV-LSTW------LLLQLPAYFELRLH 325
                   |.:|..|.::|...::|:.|..|:.::.:..:| ...|      :|..||..|.|.:.
 Worm   316 HEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIF 380

  Fly   326 DDDKLGNQRN------H-CLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQ 383
            ...|..|..|      | |:.::..|||     :....:..:::.|  ..|.||:..:...:.:.
 Worm   381 KFYKTLNIMNVQKVRWHGCVTRINSLMP-----MATSAIYVKNHFD--HEAKQQVEEMISLIMES 438

  Fly   384 F-ELVLNETEVFNEDLVTRNLARDKLRAMRL---LTPRLQDP--INGG-------PGTPQLGGNC 435
            | :|:|:|..:..|   |:..|:.|:..|:.   ....|.||  :|..       ||
 Worm   439 FVDLLLSEDWLTKE---TKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPG-------- 492

  Fly   436 DANLLQLSLSQAKLEYRQVFGEPVTSV------PADPLSVNAYYRLKLNRIELPLGLMATPLIQQ 494
              :..|...|..:...|.|. |.:|..      .|....|||:|....|.|..|.|:: .|:..
 Worm   493 --HYYQTKFSFYEQYQRDVL-ERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGIL-QPVFY- 552

  Fly   495 QCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVR 559
              ||:..:.... .|:|.::.||:.|.||..|..||..|.:.. .|....|.:|..:|.| :..:
 Worm   553 --SKDFPSSMNF-GGIGVVIGHEITHGFDDRGRLYDNLGNIRQ-WWDNATISKFEHKAQC-IEKQ 612

  Fly   560 YS-----------NATLTVNENIADTEGLRLALDTY-----RH----RSGATNL---RTFFVAFA 601
            ||           |...|..|||||..||:.|...|     ||    |....||   :.||:.:|
 Worm   613 YSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTHDQLFFLNYA 677

  Fly   602 QNWCGTVASTSGL-----SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |.||||:.....:     |:|:....||...:.|..:|...:.|:..|||||..||.:|
 Worm   678 QIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	163/708 (23%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	163/708 (23%)