DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-18

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	745	Identity:	175/745 - (23%)
Similarity:	273/745 - (36%)	Gaps:	203/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LDNDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSAN 96
            :.|..:|.|.|||:|.::.||.:    |:.::   |..|......|..|.:....:..|:.|::.
Worm    39 IKNYQNASVDPCEDFFEHTCGRY----SEHVM---DDNSWGYVQYKQLLYQVFAIARKTNKFNSK 96

  Fly    97 TSVTTSTAQLGTLYRCCL-------LSGQSIRTYTDALSRSGANFPLL-ANHTGGSFDW--VLAN 151
            .:     .||....:.||       .:.|.:|  .|...|.|  ||:: .|.....||.  :||.
Worm    97 PN-----EQLRIFTKSCLDRKEMDEDTFQDLR--NDIEERGG--FPMIDPNWNEEKFDLSDMLAK 152

  Fly   152 -----------------AALRTYGAQGLWRLLVKD------NWQSA----DQRIFYMLPPKFDLL 189
                             ||:.  |.:.:.||.|..      ||...    ...:.:||.....|.
Worm   153 YLSINRNRMGFLSVEPYAAIE--GNKSVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLE 215

  Fly   190 GRDDELNEFLYQR-YLKILLLELGLRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLVLRKPQSLK 253
            .|  ||||.:|.: :.:::.||...          ..:|..::|  .|.||.     :.|.::|.
Worm   216 NR--ELNETIYDKEFAELVQLEANF----------STLADYRNL--ALDNDN-----MSKSRNLT 261

  Fly   254 DLESQLPRLELKRYFETILEGIDW---------------DSKTLLLVADL----DYLQGLQRLLA 299
            ||...:|.             |||               |.:.||....:    :|..|..|.||
Worm   262 DLVKMIPE-------------IDWIKILKALARHGTSEEDEEKLLERVTVHGAGEYFFGENRELA 313

  Fly   300 E-HTSDP-MVLSTWL----LLQLPAYFELRLHDDD-----KLGN---QRNHCLEQLRKLMPGQLG 350
            . .|..| ..|:.:|    |:.:..||    :|.|     |..|   |::.|..|:....|
Worm   314 RIATETPKSALANYLVVRQLIDVALYF----YDKDQPRQNKFYNHVDQQSFCATQVASFFP---- 370

  Fly   351 RLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLT 415
             :....|..||.|...:. ::.|..:|..:|.::|.:..|.|..  :|..|.....||.|
Worm   371 -MPSMNVFIESSQFKIEN-LKVIEEMFVKIKAEYEQIFTENEYL--ELEIREFLIRKLNA----- 426

  Fly   416 PRLQDPING-------GPGTPQLGGNCDA-NLL------QLSLSQAKLEYRQVFGEPVTSVPADP 466
                  |:|       ..|.|.|....:. |.|      |:.:...:....|:....|...|.||
Worm   427 ------IDGKFGLDQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTPLDP 485

  Fly   467 LSV-----NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAG-LGYILAHEMVHAFDLD 525
            :::     :|.|:...|...:.|..:..|.:      :||..|..:.| |||::.||:.||||..
Worm   486 VNLKMFGTHAAYQPYPNHFYINLPYLTYPWM------DADFPANTNYGYLGYVIGHEIGHAFDHF 544

  Fly   526 GLNYDATGQLANGQW---SARAIIRFGLRAGCYLGVRYS-----------NATLTVNENIADTEG 576
            ....|.:|: ....|   :..:...:.||..| |..:||           |.|....|...|..|
Worm   545 HRKLDESGR-QQQYWFTETNSSNTEYELREKC-LRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMG 607

  Fly   577 LRLALDTY-------RHRSGATNL---RTFFVAFAQNWCGTVASTSGL------SQHAGHAERVN 625
            :|.|...:       |.|.....:   :.||..:|...| .|.:.:.|      .||..:..|||
Worm   608 IRTAFRVFEKVKKEDRFRLPGLEMSEEQLFFYNYAFRQC-DVYNPNKLPRNMLARQHPTNRYRVN 671

  Fly   626 NVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            .|:.|:|||.:.|.|...|.|||..||.::
Worm   672 GVIQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	174/740 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	172/733 (23%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	169/731 (23%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	172/733 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880