DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-22

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	159/766 - (20%)
Similarity:	279/766 - (36%)	Gaps:	191/766 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTS 98
            |..|..|.||::|:.:.|..:..||..:.||    ||:.....:.|:..|.|..::.......::
Worm    77 NGLDDTVDPCQDFYAFTCNKFLQNTDLQKLG----RSRLGTYDQAQVDVYSEIVAALSKIDVTST 137

  Fly    99 VTTST--------------------------AQLGTLYRCCLLSGQSIRTYTDALSRSGANFPLL 137
            .|:.|                          |::.:|:......|:.::|..|....:|   .:.
Worm   138 TTSKTERITKAAFETCKNNLASPADKTAVVYAEITSLFGGVPFFGEPLKTNVDYWMVAG---QIE 199

  Fly   138 ANHTGGSFDWVLANA--------ALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKF-DLLGRDD 193
            ..|..|:..:.:|::        ||.| |..||  .|.:|         ||:.|... ::..|..
Worm   200 QKHAVGTLTYTIASSDYKDHTKNALYT-GPPGL--SLARD---------FYVKPQYIAEVNQRVS 252

  Fly   194 ELNEFLYQRYLKILLLELGLRVRRAALLAEKLVAFEKSL------QKLLPNDAEQTLVLRKPQSL 252
            ::|:.| ..:.......:|.....||  |:::|.||..:      ..||.|..:|    ..|.::
Worm   253 DVNDLL-TAFANAAKKNVGADALLAA--AQEVVNFEVQIAMASWPDDLLRNYQQQ----YNPYNI 310

  Fly   253 KDLESQLPRLELKRYFETILEGIDWDSKTL---LLVADLDYLQGLQRLLAEHTSDPMVLSTWLLL 314
            ....:....:..|.|...:..|:..|:...   ::|.:..|...|..:....||:..|::.:::.
Worm   311 ASATTAYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIA 375

  Fly   315 QL---------PA-----------YFELRLHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLG 359
            ||         ||           ::.||.....|...:|.:.:..|..:..|.:..|...:..|
Worm   376 QLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGISEGCMDLLTAYMPYG 440

  Fly   360 ESYQDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNE-----DLVTRNLARDKLRAMRLLTPRLQ 419
            ..|  ||..:..:...:..|:|.|..|::|..:...:     |..::|.|.:|           .
Worm   441 TGY--VYVKSKSERNKVQADVKDQTTLIINNFQGMIDSLNWMDTFSKNRAHNK-----------S 492

  Fly   420 DPINGGPGTPQL------------GGNCD-ANLLQL------------SLSQAKLEYRQVF---G 456
            |.:....|.|:.            ..|.| |:::.|            ::.:..:|.|:.|   |
Worm   493 DSLVKNFGWPEAMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAVLKKGMEVREFFRIMG 557

  Fly   457 EPV--TSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMV 519
            ||.  |:....|..|||:|:.:.|.|..|......|......     .:|...||.|....||:.
Worm   558 EPADRTNFLQSPAMVNAWYQPERNSITFPYAAWNPPYYNLNY-----PQAYNFAGQGGTGGHELT 617

  Fly   520 HAFDLDGLNYDATGQLANGQW---------SARAIIRFGLRAGCYL-------------GVRYSN 562
            |.:|.:|:.:...|:|.:..|         |:...|..   |.|.:             .:..:|
Worm   618 HGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDM---AQCVVTQFSTQCCPEKTGNIHCAN 679

  Fly   563 ATLTVNENIADTEGLRLALDTYRH-----RSGA-----------TNLRTFFVAFAQNWCGTVAST 611
            ...|..|||||..|.:.|..:||.     |.|.           |..:.|::.:..:||...:..
Worm   680 GATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENYTPNQIFWITYGYSWCMKQSDA 744

  Fly   612 SGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQM--NPVNKCHIW 655
            :.:.|     |:....|.|.|:.::||||..|.|...|.|  .|..:|.:|
Worm   745 NLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGRCKVW 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	157/763 (21%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	155/756 (21%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	158/764 (21%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	155/756 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920