DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-21

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001360525.1	Gene:	nep-21 / 179925	WormBaseID:	WBGene00011794	Length:	864	Species:	Caenorhabditis elegans

Alignment Length:	753	Identity:	165/753 - (21%)
Similarity:	288/753 - (38%)	Gaps:	202/753 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LDNDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSAN 96
            |..:.::::.|||:|:::||||:..|.:   |.|:......:::::.:|.:.: :|......|||
Worm   185 LAENLNSKINPCEDFYEFACGNYGLNKN---LPANKPLRHTISDVQSRLNKQV-KSMLQSPISAN 245

  Fly    97 TSVTTSTAQLGTLYRCCL----LSGQSIRTYTDALSRSGA------------------NFPLLAN 139
            .......|:  ..|:.||    |....:....|...|.|.                  ...|:.|
Worm   246 EKPWDKVAK--GYYQKCLDEEELESTGVEAMRDIAKRIGGWPTLEGDKWQEWSHSWEEQIALVLN 308

  Fly   140 HTGGSFDWVLANAALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFD-------LLGRDDEL-- 195
            .||       .||.        :..:.|..:..::.:.:..:..||:.       |.|.:|.:
Worm   309 LTG-------VNAV--------ILEMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPMLR 358

  Fly   196 NEFLYQRYLKILLLELGLRVRRAALLAEKLVAFEKSLQKLLPNDAEQTLVLRKPQ------SLKD 254
            |   |...:|:..:.||    ....:|||.:......:..|.|.:...:|.|.|:      .|..
Worm   359 N---YTTLMKMTAVALG----ADPAIAEKEMNEAMEFELKLVNFSADDMVRRDPERGNNRFELWQ 416

  Fly   255 LESQLPRLELKRYFETIL-EGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLS---TWLLLQ 315
            |:|..|.:..::|.:|:. |.:.......::|.::||..|:|.:|  .::...||:   :|.|:|
Worm   417 LKSVFPFINFEKYLKTVFKELVALSPNHTVIVREIDYFVGIQHVL--QSTPKRVLANYISWRLVQ 479

  Fly   316 -------------LP-----AYFELRLHDDDKLG----NQRNHCLEQLRKLMPGQLGRLQMQLVL 358
                         ||     .:::.:.:......    ::...|:         .|..:.|.:.:
Worm   480 GGPTGDYFSFSPFLPPSAREPFYQFKANQTGMFNSPPPDRWEDCV---------TLSVIMMDMPV 535

  Fly   359 GESYQDVY---DTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQD 420
            |..:.:.:   :.|::::..|...||.:|...|:..:..:|  :||..|..|...:...:
Worm   536 GRLFVENFFEKERAMKKMTELTSYLKNEFIKQLHVLDWMDE--ITRRRAISKANMIEYKS----- 593

  Fly   421 PINGGPGTPQLGGN---CDAN----------LLQLSLSQAKLEYRQVFGEPVTSV--PAD----- 465
                  |.|.:..|   .:.|          ||.|:: :.||..   |.|.:..:  |.|
Worm   594 ------GFPMVLFNDTWMEKNWGMIIKPREYLLHLTI-RVKLVR---FTEELLRLDQPLDRSMWF 648

  Fly   466 --PLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAG---------LGYILAHEMV 519
              |..|:|||....|.:..|.|:|..|.              |:.|         :|.::.||:.
Worm   649 QSPAQVDAYYAPNNNEMIFPAGIMQFPF--------------LTLGVPNYITYGMVGAVIGHEVS 699

  Fly   520 HAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVR------------YSNATLTVNENIA 572
            ||||..|..||..|.| |..|.|....:|..:..|:  ||            :.|..|::.||||
Worm   700 HAFDDQGGQYDEMGNL-NDWWDAETEEKFIEKTRCF--VRQYENVHVVEADIHLNGQLSLGENIA 761

  Fly   573 DTEGLRLALDTYR-HRSGATNL--------------RTFFVAFAQNWCGTVASTSGL-----SQH 617
            |..|::.|.:.|: .:|..|.:              :.||:|:|.|||..|.....:     ..|
Worm   762 DNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVH 826

  Fly   618 AGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            |....|....:.|.|||...|:|...|.|||..||.:|
Worm   827 APSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	163/748 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	162/741 (22%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	162/741 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920