DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-23

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_503004.2	Gene:	nep-23 / 178472	WormBaseID:	WBGene00013785	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	167/743 - (22%)
Similarity:	263/743 - (35%)	Gaps:	219/743 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CQ--------QQLDNDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYL 84
            ||        .||.|..|....||:||:|..||..:.         |.::| .:|...|.|...:
Worm    76 CQTPECITLAHQLHNYHDPSADPCDNFYQSVCGKQHE---------HSLKS-GLAKKHLILRNLI 130

  Fly    85 EESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPLLANHTGGSFDWVL 149
            .|:.:      |..||.::.           |...:|.:....|:        ......|.|  :
Worm   131 RETIT------NRKVTPTSK-----------SENEMRKFHGICSK--------YQRANSSSD--I 168

  Fly   150 ANAAL----RTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILLLE 210
            |..||    |...:.|.|....: ||..:|          |:|   ::.||..:........|.:
Worm   169 AQQALRDIFRDVQSIGSWPAGSR-NWNESD----------FNL---NEMLNNLVKLGQRNFGLFQ 219

  Fly   211 LGLRVRRAALLAEKLVAFEKSLQKLLP---NDAEQT-LVLRKPQSLKDLE--SQLPRLELKRYFE 269
            :..:.|...|::.:  ...::..||.|   |..|.. ||..:.|.|||||  :.|..|....|:
Worm   220 ISFKYRDQLLISAE--EHRRNYSKLEPTILNIFETNGLVPDRIQLLKDLEGFASLEALLKNHYY- 281

  Fly   270 TILEGIDWDSKTLL--LVADLDYLQGLQRLLA---EHTSDPMVLSTWLLLQLPAYFELRLHDDDK 329
              |:.:|.....:|  ||..:|::..::.:::   ||....:.|.|.:|.|             .
Worm   282 --LDNMDKMKPAVLDDLVPSVDFMGLVKAMISPGKEHLMPKIELKTSVLNQ-------------T 331

  Fly   330 LGNQRNHCLEQLRKLMPGQLGRLQMQLVLG--ESYQD--VYDTAIQQ--------IAVLFRDLKQ 382
            |.|..|..||.:  ::......|...|:..  :|..|  |::|..|:        |..|.|...:
Worm   332 LFNDENMNLEAI--ILDTPKRTLANYLIFNFIDSSLDHLVFETTSQKGNTCEDKVITYLPRASLR 394

  Fly   383 QFELVLNETEVFNEDLVT------------------------RNLARDKLRAMRLLT--PRLQDP 421
            .|  :.|..:..|.||:|                        :.||.||:.||..:.  |...:|
Worm   395 VF--IRNYVDKENRDLITQLAEKTRIALHTLVQNSTWLKAESKQLALDKINAMGKMIGYPDFFEP 457

  Fly   422 INGGPGTPQLGG-----NCDA--------NLLQLSLSQAKLEYRQVFGEPVTSVPADP----LSV 469
                |||  |.|     |.|:        |.|:....:.|::|   |.|   ..|.||    ..:
Worm   458 ----PGT--LDGMFKNLNLDSSDTYYTALNKLERYFVEQKMDY---FAE---ETPLDPDLRVFEM 510

  Fly   470 NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGL------- 527
            ||||.:..|::.........|:.........:.     |..|.|:.|||.|||....:
Worm   511 NAYYYIPGNQLNFLAPFFDDPMFDSTYPDYVNI-----AMSGNIIGHEMGHAFGPHAILRTVRGR 570

  Fly   528 ----------NYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSNATLTVNENIADTEGLRLALD 582
                      .|::..|....|:|......||         |..:....::|.:||..|..::..
Worm   571 EVWMKPEELAEYESRAQCLANQYSEYDDPDFG---------RVFDGGKVIDELVADNIGREVSWK 626

  Fly   583 TYR--HRSGATNL---------RTFFVAFAQNWC---------GTVASTSGLSQHAGHAERVNNV 627
            .::  ..:.||.:         :.:|...|...|         |::.|:     |...|.|||.|
Worm   627 MFKSLDLTNATRIIGFEDYDIDQLYFRVGALTHCTPHAMRDLKGSIESS-----HPRKAFRVNGV 686

  Fly   628 VGNMPEFGDTFECKATSQMNPVNKCHIW 655
            ..|:|||...|.|...|.|||..||.::
Worm   687 YANLPEFARAFNCPTGSPMNPRKKCDMF 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	162/726 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	160/719 (22%)
nep-23	NP_503004.2	M13	96..711	CDD:189000	159/718 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920