DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-16

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001023203.2	Gene:	nep-16 / 177541	WormBaseID:	WBGene00018472	Length:	868	Species:	Caenorhabditis elegans

Alignment Length:	728	Identity:	152/728 - (20%)
Similarity:	257/728 - (35%)	Gaps:	203/728 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DCQQQLDNDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEE--SSS 89
            |...:|.:..|.|::|||||::|:|..::|.|:       |.:..:::.||.:.:|.:..  ||.
Worm   241 DIAFRLSSCIDDEIEPCENFYRYSCQRYHSQTA-------DKQMSFLSQLKDESLRRMHSLLSSE 298

  Fly    90 TDSFSANTSVTTSTAQLG-TLYRCCLLSG-QSIRTYTDALS--RSGANFPLL---ANHTGGSFDW 147
            .||     .:...:|:|. :||..|:.:. :|....||.|:  |:....|||   .|....|:.|
Worm   299 EDS-----RLLPKSARLSRSLYSACMNAVLRSSNAPTDLLTFIRNFPCGPLLRDCQNFHADSYSW 358

  Fly   148 VLANAALRTYGAQGLWRLLVKD---NWQSADQRIFYMLPPKF----DLLGRD------DELNEF- 198
            ......|..|.  |.:.|:|.|   :.|...:.|..:.||..    .|:.||      ....||
Worm   359 ERHAGMLDWYA--GRYNLIVYDRDVHPQDRSKIILQIKPPDLTPIVGLIERDLIDLARPSPTEFE 421

  Fly   199 ------LYQRYLKILLLELGLRVRR---------AALLAEKLVAFEKSLQKLLPNDAEQTLVLRK 248
                  |.|..|.....:..||..|         |.|:.:..::..:| ..|.||....|
Worm   422 PLLQLSLRQNLLSAFARDSLLRDPRDVQSQLDEVARLMVDLYISARQS-ASLTPNTTYMT----- 480

  Fly   249 PQSLKDLESQLPRLELKRYFETILEG-IDWDSKTLLLVADLDYLQGLQRLLAEHTSDP-----MV 307
               :.::...||:|.|:.:.:..|.. ..|....:|.:.|.||...|..::|:.:...     :.
Worm   481 ---IGEMFQALPQLYLREFLDAQLSNTYRWTETDMLSIQDYDYFARLSDIMAQTSRQAVANYLLT 542

  Fly   308 LSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQ 372
            ::.|.|.|. :|     ...|:.|  ...|::|:...   ::||   ::.:.::.|.:....||:
Worm   543 VTVWNLKQY-SY-----SPRDQYG--WRECVDQISSF---EIGR---KMYVDKASQTIDLPKIQE 593

  Fly   373 IAVLFRDLKQQF-------------------------------ELV--------LNETEVFNEDL 398
               ..::||..|                               ||:        ||||:.|:..:
Worm   594 ---FLQNLKIDFLSVHRSTPLQYLSNINRLGFYVGFPRRLQNEELIWKPVSQVSLNETDYFDSMI 655

  Fly   399 VTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSLSQAKLEYRQVFGEPVTSVP 463
            ......||...:                   |:|...|                   .:..|:.|
Worm   656 RVGKAERDYTMS-------------------QIGTYLD-------------------NDDTTTFP 682

  Fly   464 -ADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGL 527
             :||..:   |...:..|.:||..:..|:   ....:......:.:.|| |...:|:......||
Worm   683 ISDPTML---YNSNVGAIVIPLAFIEPPI---YLPGDEVPMYGIYSSLG-ITTLQMISKVFWQGL 740

  Fly   528 NYDATGQL------------ANGQWSAR------AIIRFGLRAGCYLGVRYSNATLTVNENIADT 574
              |.|.||            ||.|.|..      |.|..   |..:....||.|....:.:|...
Worm   741 --DKTSQLECLDNVFRGFLDANRQRSPNIEPELLATIEL---ADAFKSALYSYAKWQNDHHIHHE 800

  Fly   575 EGLRLALDTYRHRSGATNLRTFFVAFAQNWCGTVASTSGLSQHAGHAERVNNVVGNMPEFGDTFE 639
            :.|. |.|:      ..::|:..:.|:..:|....|..|....|    .:|.|..|...|...|.
Worm   801 KTLP-AFDS------TDSMRSLMLTFSTMFCSGEGSEPGSDYEA----MINTVAENSRMFSIHFN 854

  Fly   640 CKATSQMNPVNKC 652
            |..:|::.....|
Worm   855 CNNSSRLYNRRTC 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	150/720 (21%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	148/715 (21%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:387391	110/554 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010