DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-26

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	817	Identity:	172/817 - (21%)
Similarity:	307/817 - (37%)	Gaps:	237/817 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KPPLSSITRLVVILGVMLLKL------------------AAAQDC---QQQLDNDTDAEVKPCEN 45
            |..:||.::..::|.|:::.|                  ..:::|   ..:|....|..|:||:|
Worm    65 KEAISSSSKGCLLLTVLVIFLFVTLSFAIACFLYYQTLPCTSEECVMTASRLLKRVDQSVEPCDN 129

  Fly    46 FHQYACGNWYS----------NT---SQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANT 97
            |:|:|||.|.:          ||   :||.  |||           |:::.:.:.:. .|:...|
Worm   130 FYQFACGGWINQSVNLKYDSWNTLYETQRT--AHD-----------QIVQAMHKIND-GSYPLPT 180

  Fly    98 SVTTSTAQLGTLYRCCLLSGQSIRTYTDALSRSGAN-FPLLANHTGGSFDWV--LANAALRTYGA 159
            :.....|  ..:|..|:        .||.|.::|.: :....:..||   |:  |.|.||....:
Worm   181 NAGERAA--AKMYEQCM--------DTDTLEQTGLHLWERFVDELGG---WMPELKNGALEQEES 232

  Fly   160 ---------QGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILLLELGLRV 215
                     :...|..::|...||   ..|.:   |.|.....|:|....:.:|..:..:|.:
Worm   233 FEIELDEDEKKRRRFEIEDIILSA---FNYSV---FPLFWAGVEVNYLNSKEHLITIYEQLPI-- 289

  Fly   216 RRAALLAEKLVAFEKSL-QKLLPNDAEQTLVLRKPQSL-KDLESQLPRLELKRYFETILEGID-W 277
                |||.:...:.|.| .:::....|...|.|..|.: ::|.:.|              |.| .
Worm   290 ----LLAPEKYHYNKELTPEMIYGKMEGPPVTRALQQVGEELSAVL--------------GFDST 336

  Fly   278 DSKTLLLVADLDYLQ-------------------------------------GLQRLLAEHT--S 303
            |.|..:::|::.||:                                     .|.||:.|:.  |
Worm   337 DEKVRMMIANMIYLEYQITMAGSTFYKEKKERYTVVMLRELQEIAPAINWHYFLSRLVGENLSHS 401

  Fly   304 DPMVLST------------------------------W--LLLQLPAYFELRLHD---------- 326
            :|:.|.|                              |  ::..| ||...:..|
Worm   402 EPIALKTGTQWIPILSAIVEKLKQSRSGVAVLKNYVKWKTIMFHL-AYASPKCRDGLLWMAVSLY 465

  Fly   327 DDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFELVLNET 391
            ......::..|:.:|..:.|..|..: ::.:.|..:.:....|:|.||   ..:::::|.::..:
Worm   466 SGAASQRKEFCVLRLSGIFPLSLPSI-LRKIDGIDHTEKNVKAVQNIA---DRIQEKYEEMVRSS 526

  Fly   392 EVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQL-------------S 443
            .:|: |..||....||:..|....        |.|...:.....:...::|             |
Worm   527 NLFS-DRETRENVIDKVNNMTKFI--------GFPDAMRSDYEMEKEAVRLHDTLFWSMVLGSSS 582

  Fly   444 LSQAKLEYRQVFGEPVTSVPADP-LSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLS 507
            :.:.:|:..::..:|.:.|...| :||.| :..:.|.:::|...:..|...:.....|:     .
Worm   583 VYKERLQRLRLPVDPRSWVDTRPAISVPA-HNYERNLVQIPFDSLRLPYADEHQLDFAN-----Y 641

  Fly   508 AGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGC----YLGVRYSN----AT 564
            ||:|.|:.||:.||||..|..:..||.| ...||..:|..|..|..|    |.|:..|:    |.
Worm   642 AGIGTIIGHELTHAFDGQGKLHGPTGNL-GVWWSTDSIREFKAREQCFVKQYAGLMDSHDMNAAK 705

  Fly   565 LTVNENIADTEGLRLALDTYRHRSGATNLR-----------TFFVAFAQNWCGTVASTSGLSQHA 618
            ..:.|||||..||::|.:.::......:.|           .||:|:.|.||...:.:..|..|.
Worm   706 EGLYENIADQVGLKVAYEAWKSNGNQNSGRMPGLEKYSQDQLFFLAYTQGWCALRSKSYKLQPHM 770

  Fly   619 GHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            ....|:...:.|.|||...::|.:.|.|||.:||.||
Worm   771 EERIRMLGSLQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	162/761 (21%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	160/754 (21%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	163/769 (21%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	160/754 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020