DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-5

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001364754.1	Gene:	nep-5 / 173933	WormBaseID:	WBGene00017393	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	141/736 - (19%)
Similarity:	263/736 - (35%)	Gaps:	192/736 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSSITRLVVI------LGVM----------------LLKLAAAQDCQ--------QQLDNDTDAE 39
            |:.||.||::      ||.:                .|::.....||        .:|....|:.
Worm    63 LAVITTLVILVLLIFALGALGLHDISAFKWEPKPQKALRIMLDLPCQTKECVKYSAELLELMDSS 127

  Fly    40 VKPCENFHQYACG--NWYSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTS 102
            |.||||||.:.|.  |......:|::...:::.|......:.::|.:....:...       |..
Worm   128 VNPCENFHHHVCNGFNPRKKDFERLMKLINIQEKPDHRKAVNVVRRMLSKCAMGK-------TEE 185

  Fly   103 TAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPLLANHTGGSFDWVLANAALRTYGAQGLWRLLV 167
            ..|:|.|               .::...|..||||.|......|.:..:.:..||....|.::|.
Worm   186 IHQVGRL---------------SSIILPGLPFPLLNNSWTKPSDPISTSNSSTTYSYPFLTKILA 235

  Fly   168 KDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILLLELGLRVRRAALLAEKLVAFE-KS 231
            .....:.|...|..:.|     ..|.|.:.|:.:.:..:                  |..|: ::
Worm   236 HIILHNPDDAGFVGIKP-----SSDSEFSLFVVKPFSPV------------------LTNFKFRN 277

  Fly   232 LQKLLPNDAEQT-------LVLRKPQSLKD---LESQLPRLELKRYFETI--------LEGIDW- 277
            :..:|..:|.::       |...:.:.|.|   |:::|.::|.|...|.:        :..|||
Worm   278 MYDILKRNAPESSTNGMIDLEFDRQRQLNDVIKLQTKLEKIEFKADPEVVNLTEIQRQMPIIDWK 342

  Fly   278 ---DS---------KTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKL 330
               ||         |..:...:..|.:.:..:::...|:  .:..:|.|:    |..:....:..
Worm   343 RLIDSWIPNGYAHLKEKVYGFNTSYYEEINAIISSTPSE--TIYNFLFLR----FSFKFLRTEVA 401

  Fly   331 GNQRNHCLEQLRKLMPGQL---GRLQMQL--VLGESYQDVYDTAIQQIAVL-FRDLK--QQFELV 387
            .:..:.||.||...:||::   |..:.:.  :|......:.|...:.:|.| :.|.:  ::.:..
Worm   402 SDLEDTCLHQLSTTIPGKIVLYGSEEPEALNLLNGMLHTIKDQLKRSLATLKWMDSRGIEEAQKK 466

  Fly   388 LNETE-VF---NEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSLSQAK 448
            .|:|: ||   .|||:      |:|               .|..||:  .|..:.|..:.|.|.:
Worm   467 FNKTKTVFGFTGEDLI------DEL---------------VGKITPE--SNYISTLQNVLLWQTR 508

  Fly   449 LEYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYI 513
            ..::.|....||..    |:...:|.::.|.|.:...|:..|.:........:     .|.:...
Worm   509 NMFKSVAENNVTVF----LNSEVFYSVEKNEITISRALLHYPFMSANLPNYTN-----FATIASK 564

  Fly   514 LAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCY-------LGVRYS---NATLTVN 568
            :..:|:|.||..|..||:.|...| .|:......|.:...|:       .||..|   ||..:..
Worm   565 ILPQMIHIFDERGRFYDSDGNHRN-WWNTETERYFQIIVQCFDGMMQNVFGVSVSIGWNAYDSTK 628

  Fly   569 ENIADTEGLRLALDTYRHRSGATNLRTFFVAFAQNWCGTVASTSGLSQHAGHAERVNNVVGNMPE 633
            |..|...|::.:.|.          ..||.:..:..|            ....:.||..:.::|:
Worm   629 EPYATLPGIQQSSDE----------ALFFYSMVKTMC------------TSDPDNVNEALASVPQ 671

  Fly   634 FGDTFECKATSQMNPVNKCHI 654
            |...|:|...::|||..||.:
Worm   672 FNSAFKCNNGTKMNPPTKCKL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	130/676 (19%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	128/668 (19%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	128/668 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810