DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-12

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	172/744 - (23%)
Similarity:	292/744 - (39%)	Gaps:	198/744 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NDTDAEVKPCENFHQYACGNWYSNTSQRILGAHDMRSKWVANLKLQLIRYLE---ESSSTDSFSA 95
            |:.:.:..|||:|:::|||.:   .:::::..|:.:...::.:|.::.|:|:   |.:|.::
Worm   165 NNMNRDANPCEDFYEFACGKY---ATRKVIAEHEKKVTVLSEMKKEMDRHLKDILEKTSREN--- 223

  Fly    96 NTSVTTSTAQLGTLY-RCCL----LSGQSIRTYTDALSRSGANFPLLANHTGGS--FDWVLANAA 153
                ||.:.:|..:| ..|:    .....::.....:|..| .:|||.|....|  |.|.:....
Worm   224 ----TTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLG-GWPLLTNARFDSIDFQWEVLAGH 283

  Fly   154 LRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEF------------LYQRYLKI 206
            |..||..|::|:.|..::..:|:.:....|||..|     |..:|            .|::|:..
Worm   284 LALYGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFL-----EKKKFYREVPSSNVYLQYYRQYILS 343

  Fly   207 LLLELGLRVRRAALLAE----KLVAFEKSLQKLLPNDAEQTLVLRKPQSLKDLESQLPRLELKRY 267
            ||..||:.:.....:.|    .::.||:.:                        :.|.|:||.|.
Worm   344 LLSLLGVDMEDETGVIEYQVDDIIDFERRI------------------------ANLTRIELSRN 384

  Fly   268 FETI------------LEGIDWDS---------------KTLLLVADLDYLQGLQRLLAEHTSDP 305
            ..:|            .:.|:||:               ..::.|.|::|...|..|:   .|.|
Worm   385 HSSINNMITFGEFKRKYDKINWDAFFNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLI---KSKP 446

  Fly   306 MVLST------WLL-----LQLPAYFELRLHD----------DDKLGNQRNHCLEQLRKLMPGQL 349
              ||:      |.|     :.|||.:...:.|          ||.|...   |:.::|:
Worm   447 --LSSINNFLMWCLVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDPLWEV---CVGEVRE------ 500

  Fly   350 GRLQMQLVLGESYQDVYDTAIQQIAV--LFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAM- 411
               .:.:.|...|...:.|...::..  :.||||:..|..|...:..:|.  ||..|..||.||
Worm   501 ---NLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKKAMEQTLLNADWIDES--TREAALMKLDAMG 560

  Fly   412 -RLLTPRLQDPINGGPGT---------PQLGGNCDAN-LLQLSLSQAKLEYRQVFGE----PVTS 461
             ::          |.|.:         |..|....|| ....::|..|..||....:    |...
Worm   561 HKI----------GFPDSLLNETAVLLPYAGVRLTANQYFDNAISLKKAAYRDALSKLHRTPSLI 615

  Fly   462 VPADP-LSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAG-LGYILAHEMVHAFDL 524
            ..|.| ::|:|::....|.|..|.|::..|:.      ..|..|..:.| :|..:.||:.|.:|.
Worm   616 DWASPIIAVDAFHYFTGNEIIFPAGILQFPMF------VPDAPAFSNYGAIGMGIGHEITHGYDD 674

  Fly   525 DGLNYDATGQLANGQWSARAIIRFGLRAGCYLGV----------RYSNATLTVNENIADTEGLRL 579
            .|..||..|.| .|.|....:..|..:..|::..          |..:..:|:.|||||..|||:
Worm   675 LGAQYDDKGNL-RGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMTIGENIADNGGLRV 738

  Fly   580 ALDTYRHRS----------GATNL---RTFFVAFAQNWCGTVASTS-----GLSQHAGHAERVNN 626
            |...|:.||          |.|:.   :.||:|:|..||..:..::     ....|:....|||.
Worm   739 AFQAYQLRSDREKETRRLPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFRVNV 803

  Fly   627 VVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            .:.|:|.|...|:|...|.|||..||.||
Worm   804 PLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	169/741 (23%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	168/734 (23%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	168/734 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880