Protein Alignment Nep6 and Mme

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_032630.2
• Gene: Mme / 17380
• MGIID: 97004
• Length: 750
• Species: Mus musculus
• Alignment Length: 775
• Identity: 172/775 - (22%)
• Similarity: 301/775 - (38%)
• Gaps: 179/775 - (23%)

  Fly     5 LSSITRLVVILGVMLLKLAAAQD---CQQ--------QLDNDTDAEVKPCENFHQYACGNWYS-- 56
            ||.:..|:.|:.|.::.|.|..|   |:.        :|..:.||.|:||.:|.:||||.|..
Mouse    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRN 95

  Fly    57 ---NTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQ 118
               .||.|......:|.:    |::.|...|:|..:.|        ..:..:..||||.|:
Mouse    96 VIPETSSRYSNFDILRDE----LEVILKDVLQEPKTED--------IVAVQKAKTLYRSCI---- 144

  Fly   119 SIRTYTDALSRSGANFPLLA---------------NHTGGSFDWVLANAALR---TYGAQGLWRL 165
                ...|:...|.. |||.               :.|.|: .|....:..:   .||.:.|...
Mouse   145 ----NESAIDSRGGQ-PLLKLLPDIYGWPVASDNWDQTYGT-SWTAEKSIAQLNSKYGKKVLINF 203

  Fly   166 LVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQR----YLKILLLELGL-RVRRAALLAEKL 225
            .|..:.:::.|.|.:...|:..|..||......:|:.    |:..::....| |..::..:.|..
Mouse   204 FVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQ 268

  Fly   226 VAFEKSLQKLLPNDAEQTLVLRKPQSLKD---LESQLPRLELKRYFETILEG--IDWDSKTLLLV 285
            ::.|  :.|::..:.|......||:...|   |.:::...:|:..|...:.|  ..|.:.|..::
Mouse   269 LSLE--MNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIM 331

  Fly   286 ADL---------------DYLQGLQRLLAEHT-SDPMVLSTW-LLLQLPA-----YFELR----- 323
            :.:               :||..|:.:|.::: .|...|.:| .::.|.:     |.|.|
Mouse   332 STVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRK 396

  Fly   324 -LHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLF---------- 377
             |:...........|...:...|...:|||.::.......:.|.:..|.||..:|
Mouse   397 ALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWM 461

  Fly   378 -RDLKQQFE---LVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDAN 438
             .:.|::.|   |.:.|...:.:|:::.   .:||....|.....:|             ....|
Mouse   462 DAETKKKAEEKALAIKERIGYPDDIISN---ENKLNNEYLELNYRED-------------EYFEN 510

  Fly   439 LLQ-LSLSQAK--LEYRQ-------VFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQ 493
            ::| |..||:|  .:.|:       :.|..|         |||:|....|:|..|.|::..|...
Mouse   511 IIQNLKFSQSKQLKKLREKVDKDEWISGAAV---------VNAFYSSGRNQIVFPAGILQPPFFS 566

  Fly   494 QQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYL-- 556
            .|.|...:     ..|:|.::.||:.|.||.:|.|::..|.|.: .|:.::...|..::.|.:
Mouse   567 AQQSNSLN-----YGGIGMVIGHEITHGFDDNGRNFNKDGDLVD-WWTQQSANNFKDQSQCMVYQ 625

  Fly   557 ---------GVRYSNATLTVNENIADTEGLRLALDTYRH---RSGATNL---------RTFFVAF 600
                     |.::.|...|:.|||||..|:..|...|::   ::|...|         :.||:.|
Mouse   626 YGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNF 690

  Fly   601 AQNWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            ||.||||......::.     |:....|:...:.|..||.|.|.|:..|.|||..||.:|
Mouse   691 AQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	158/725 (22%)
Mme	NP_032630.2	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	77..748	CDD:341056	158/725 (22%)