DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and nep-9

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_494531.2	Gene:	nep-9 / 173683	WormBaseID:	WBGene00017554	Length:	700	Species:	Caenorhabditis elegans

Alignment Length:	772	Identity:	157/772 - (20%)
Similarity:	278/772 - (36%)	Gaps:	239/772 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVILGVMLL--------KLAAAQDCQ--------QQLDNDTDAEVKPCENFHQYACGNWYSNTSQ 60
            ::::|:..|        .....|.|:        |:|...:|...|.||:|::..|.|:   ...
Worm    40 IIVVGLFTLYTFHFHSKSRVTPQFCESPQCIILAQELKAYSDTATKSCEDFYKATCENY---KDH 101

  Fly    61 RILGAH-DMRSKWVANLKLQLIR-YLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTY 123
            :.|..| |.:.:...|   :|:| :|:...||     .||.:.|..:|  ::..|
Worm   102 QALDRHRDCKKRKAVN---KLVRGFLQRDEST-----FTSESESAIKL--IFGKC---------- 146

  Fly   124 TDALSRSGANFPLLANHTGGSFDWVLANAALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDL 188
             |.|||:.:...:..:              ::..|:   |.:| :.||:.:          .|:|
Worm   147 -DELSRNTSYLDIFKD--------------IKKIGS---WPVL-EHNWKDS----------MFNL 182

  Fly   189 LGRDDELNEFLYQRYLKILLLELG--------LRVRRAALLAEKLVAFEKSLQKLLPNDAEQTL- 244
               ||.:.:          |::||        |.:|:.|.  .....|..|.|:...:..|:|:
Worm   183 ---DDVIAK----------LVKLGSTDFGLFKLELRKLAF--GHFAVFVSSKQEQNIHQLEKTIL 232

  Fly   245 -VL--------RKPQS------------LKDLESQLPRLELKRYFETILEGIDWDSKT---LLLV 285
             :|        ||..|            ||:...:...:|.:.|..:|:|.:...|.|   .|..
Worm   233 GILKANGIQQDRKELSDDLKDYSDFKNHLKEFYQEETYIEYRLYAGSIVENLGISSLTTQMALKS 297

  Fly   286 ADLDYLQGL-QRLLAEHTS----------------DPMVLSTWLLLQLPAYFELRLHDDDKLGNQ 333
            ..||....: ||.|..::|                ....|:.:|:..   :.::...|   |.|.
Worm   298 TGLDVFNHVNQRTLITNSSLFFGEENNLGMIIQKTPKRTLANFLIFH---FIDVMTTD---LANA 356

  Fly   334 RNHCLEQLRKLMPGQLGRLQMQLVLGESY--QDVYDTAIQQIAVLFRDLKQQFELVLNETEVFNE 396
            ...|.|.|..|:|    |..:| ||..::  :|..|..::    :.:|||.:...:::.:..|.:
Worm   357 TKACKETLIDLLP----RASIQ-VLSRNFVNEDAQDDMVK----MAQDLKTKITEMIDNSPFFTK 412

  Fly   397 -----DLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSLSQAKLEYRQV-- 454
                 |...:.....|::|:.::|...|:.:             |.:..:|:|:.:...||.:
Worm   413 FHLVFDAEEQKKLIQKVKAIGIVTEYPQEVL-------------DRDFERLNLTPSDSIYRTIQK 464

  Fly   455 ------------FGEPVTSVPADPLSV----NAYYRLKLNRIELPLGLMATPLIQQQCSKEADTR 503
                        .|..:     ||...    :|:|....|.:.:...::..|..........:..
Worm   465 LRRLRSEQLIEHLGGDL-----DPTDTRVWGSAHYDQTTNNLTIFAPIIDGPYFDTSYPNYVNQF 524

  Fly   504 AKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQW-SARAIIRFGLRAGCYL----------- 556
            .     :|:||..|:..:.|...:..|..||..|  | ...::.||.....|:.
Worm   525 L-----MGFILGRELGRSLDSVRIRKDEKGQTEN--WLKPESLKRFDEHLKCWAEKYDKSADPLK 582

  Fly   557 ----GVRYSNATLTVNENIADTEG--------LRL------ALDTYRHRSGATNL-RTFFVAFAQ 602
                |:|........||..||..|        ::|      .|:|::    ...| |.||...|.
Worm   583 SESKGIRQIEGRYIQNEMFADFIGHEASWRAFMKLDVKNEEVLETFK----VIKLRRMFFNVQAL 643

  Fly   603 NWCGTVA-STSGLS---QHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
            .:|...: ||..||   .|..::.|||....|||:|...|||.:...|||.|||.::
Worm   644 YFCRPPSGSTDWLSYQEHHQHYSFRVNGAFKNMPQFALAFECASDDDMNPQNKCSMF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	151/731 (21%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	149/724 (21%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	148/721 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910