Protein Alignment Nep6 and Nep4

DIOPT Version :10

• Sequence 1: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_061501026.1
• Gene: Nep4 / 1273777
• VectorBaseID: AGAMI1_013990
• Length: 1007
• Species: Anopheles gambiae
• Alignment Length: 801
• Identity: 190/801 - (23%)
• Similarity: 299/801 - (37%)
• Gaps: 221/801 - (27%)

  Fly    29 QQQLDNDTDAEVKPCENFHQYACGNW-YSNTSQRILGAHDMRSKWVANLKLQLIRYLEES----- 87
            :|.:|.|.|    ||::|:||||||| ..|...:...|.|.......:|.|.|.:.|.|.
Mosquito   254 KQYMDPDAD----PCDDFYQYACGNWDRVNPIPKDKAALDTFELLRESLDLVLKQLLLEGEPAGL 314

  Fly    88 -----------SSTDSFSANTSVTTSTAQLG-------------TLYR----------------- 111
                       |..|....:||.||:.|..|             .|:|
Mosquito   315 LDVENALSTVRSQPDGTKKSTSTTTTAASAGWPTTTVTGGPAQQQLHRVRKRGRAENRNRSGRAV 379

  Fly   112 ---CCLLSGQ-------------------------SIRTYTDALSRSG-----------ANFPLL 137
               ..:.|.|                         |...| :.:.|.|           ..:|:|
Mosquito   380 QNKLIIRSAQVKRVRRKRELLINDDAEMKARHLFVSCMNY-ELIERRGLEPLRTLLHSLGGWPVL 443

  Fly   138 ANHT--GGSFDWVLANAALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDEL---NE 197
            ..||  ..||||:...||||.|....|....|..:.:::|:.|.........|..||..|   |.
Mosquito   444 EPHTWDESSFDWLNLTAALRRYNNDVLIVEWVGPDIKNSDENIVQFDQTSLGLPTRDYYLQPGNR 508

  Fly   198 FLYQRYLKILLLELGL------RVRRAALLAEKLVAFEKSLQKL--LPNDAEQTLVLRKPQSLKD 254
            ...:.|.:.:|..:||      ..|:|   .::::.||..|..:  .|.:......|.:...|..
Mosquito   509 KYLEAYRQFMLEVIGLLDVPADTARQA---TDEMIEFETQLANITSTPEERNNVSTLYRKLMLDQ 570

  Fly   255 LESQLPRLELKRYFETILEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAY 319
            |:.::|::....|. ||:.....:..:.:::..:.|::.|..|:.:  ::|.:::.:||.:   :
Mosquito   571 LQEEVPQINWTHYL-TIVTERPVNGSSFVVMFAMSYMRDLVELIDQ--TEPRIVANYLLWR---F 629

  Fly   320 FELRLHD-DDK------------LGNQRN-----HCLEQLRKLMPGQLGRLQMQLVLGESYQDVY 366
            ...|::: ||:            .|.:||     :|:.|:...|...:|.:.::....|:.:
Mosquito   630 VRHRINNLDDRFLGAKQRFSNALFGRERNPPRWKNCVTQVNANMGMAVGAMFVRRYFDENSK--- 691

  Fly   367 DTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQL 431
                :....:..:|:..|..:|..|...  |:.||.||..|:.||.|   |:        |.|..
Mosquito   692 ----RDTLTMTHELQDAFREILGRTGWI--DMATRQLAEQKVNAMSL---RI--------GYPDF 739

  Fly   432 GGNCDANLL---QLSLSQAKLEY--------------------RQVFGEPV--TSVPADPLSVNA 471
                   :|   |||...|.||.                    ::..|:||  |:....|..|||
Mosquito   740 -------ILDPEQLSARYATLEIHPDRYFENTLNVLSHIRRTDQEKLGQPVNKTAWHTAPAVVNA 797

  Fly   472 YYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLA 536
            ||....|:|..|.|::..|...:...|..:     ..|:|.::.||:.|.||..|..:|..|.|.
Mosquito   798 YYSRNKNQIMFPAGILQPPFYHRHLPKAIN-----YGGIGVVIGHELTHGFDDKGRLFDRDGNLY 857

  Fly   537 NGQWSARAIIRFGLRAGCYLGV--RYSNATL--------TVNENIADTEGLRLALDTYRHRSGA- 590
            . .||.|||..|..||.|.:..  ||..|.:        |..|||||..|::.|...|.....|
Mosquito   858 R-WWSDRAIEEFHERAACLVEQYGRYRIAEVDVQLDGENTQGENIADNGGIKQAFLAYSKWLAAQ 921

  Fly   591 ----------------TNLRTFFVAFAQNWCGTV--ASTSGLSQHAGHAE---RVNNVVGNMPEF 634
                            |..:.||:.|||.|||.:  .:|....:.|.|:.   ||...:.|..:|
Mosquito   922 TDRRVLEAETLPGLNVTRTQLFFLNFAQIWCGAMRPEATRNKLKTAVHSPGRFRVIGTLSNSEDF 986

  Fly   635 GDTFECKATSQMNPVNKCHIW 655
            ...:.|...|.|||..||.:|
Mosquito   987 AREYHCPVGSTMNPPGKCSVW 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_572831.2	M13	40..653	CDD:341056	184/786 (23%)
Nep4	XP_061501026.1	None