DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and Ece2

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	757	Identity:	181/757 - (23%)
Similarity:	298/757 - (39%)	Gaps:	156/757 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SITRLVVILGVMLLKLAA---------------------AQDCQQ---QLDNDTDAEVKPCENFH 47
            |.|:|.::|..::|.|||                     .:.|.:   ::....|..|.||::|:
Mouse    55 SHTQLELVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFY 119

  Fly    48 QYACGNWYSNTSQRILGAHDMRSKW-----VANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLG 107
            |::||.|.....     ..:.||:|     :.:....::::|.|:::.:|.|.....|.|
Mouse   120 QFSCGGWIRRNP-----LPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRS----- 174

  Fly   108 TLYRCCLLSGQSIRTYTDALSRSGANFPL--LANHTGG----------SFDWVLANAALRTYGAQ 160
             .|..||.|        :.:.:.||. ||  |.:..||          ||..|| .|...||.|.
Mouse   175 -FYLSCLQS--------ERIEKLGAK-PLRDLIDKIGGWNITGPWDEDSFMDVL-KAVAGTYRAT 228

  Fly   161 GLWRLLVKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQRYLKILLLELGLRVRRAALLAEKL 225
            ..:.:.|..:.:|::..|..:......|..||..||....:   |:|...|...|....||..:.
Mouse   229 PFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANE---KVLTAYLDYMVELGVLLGGQP 290

  Fly   226 VAFEKSLQKLL-----------PND--AEQTLVLRKPQSLKDLESQLPRLELKRYFETILEGIDW 277
            .:..:.:|::|           |.|  .::..:..| .|:.:|::..|.::...:...:|..::.
Mouse   291 TSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHK-MSISELQALAPAVDWLEFLSFLLSPLEL 354

  Fly   278 DSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLR 342
            .....::|...:|||.:..|:  :.::|.:|:.:|:..|.......|  |.:....:...||.|.
Mouse   355 GDSEPVVVYGTEYLQQVSELI--NRTEPSILNNYLIWNLVQKTTSSL--DQRFETAQEKLLETLY 415

  Fly   343 KLMPGQLGRLQ---------MQLVLGESY-QDVYDTAIQQIAV-LFRDLKQQFELVLNETEVFNE 396
            ........|.|         :...||..: :..:|...::||. :..:::..||..|.:....:|
Mouse   416 GTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDE 480

  Fly   397 DLVTRNLARDKLRAMR--------LLTPRLQDPINGGPGTPQLGGNCDA---NLLQLSLSQAKLE 450
            .  ||..|::|..|:.        :|.|:..|.:..|....:     |:   |:|.|....||
Mouse   481 K--TRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSE-----DSFFQNMLNLYNFSAK-- 536

  Fly   451 YRQVFGEPVTSVPA------DPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAG 509
               |..:.:...|:      .|.:|||||....|.|..|.|::..|.......|     |....|
Mouse   537 ---VMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPK-----ALNFGG 593

  Fly   510 LGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYS---------NATL 565
            :|.::.||:.||||..|..||..|.| ...|...::..|.....| :..:||         |...
Mouse   594 IGVVMGHELTHAFDDQGREYDKEGNL-RPWWQNESLTAFQNHTAC-MEEQYSQYQVNGERLNGLQ 656

  Fly   566 TVNENIADTEGLRLALDTY-----RHRS-------GATNLRTFFVAFAQNWCGT---VASTSGL- 614
            |:.|||||..||:.|.:.|     :|..       |.||.:.|||.|||.||..   .:|..||
Mouse   657 TLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLV 721

  Fly   615 -SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655
             ..|:....||...:.|..:|...|.|...|.|||...|.:|
Mouse   722 TDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	171/703 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	169/696 (24%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	169/696 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020