DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep6 and mme

DIOPT Version :9

Sequence 1:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	789	Identity:	178/789 - (22%)
Similarity:	312/789 - (39%)	Gaps:	189/789 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPPLSSITR----LVVILGV----MLLKLAAAQD--CQQQLDNDT--------DAEVKPCENFH 47
            |||.||.:.:    |.:.||:    |:|..|.:.|  |..|....|        ||...||.:|:
Frog    13 MKPGLSPLEKGLIILCIFLGIISIAMILAYATSNDGICTSQACISTAARIIANMDAATDPCNDFY 77

  Fly    48 QYACGNW-----------YSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTT 101
            |||||.|           .|||...:.          .::::.|...||:.|:.|        ..
Frog    78 QYACGGWLKKNRIPDNNIVSNTFDILR----------TDIEVVLKDALEKESADD--------IP 124

  Fly   102 STAQLGTLYRCCLLSGQSIRTYTDALSRSGANFPLLANHTGGSFDWVLA---------------- 150
            :..::.|.|:.|:  .::|:.    |.:.|   ||:.. ....:||.:|
Frog   125 AIKKVKTFYKSCI--DETIKN----LRKGG---PLIKT-LPALYDWPIAVDNWETRYGLVWSAQE 179

  Fly   151 --NAALRTYGAQGLWRLLVKDNWQSADQRIFYMLPPKFDLLGRD-------DELNEFLY-QRYLK 205
              ...:..||..||..:.|.::..::...|.::..|...|..:|       .|:....| ::.:.
Frog   180 SIAGFITKYGQSGLINVYVSEDLTNSSTYILHIDQPGLGLPSKDYYDCKGTSEIACLAYMEQMVS 244

  Fly   206 ILLL---ELGLRVRRAALLA--EKLVAFEKSLQKLLPNDAEQTLVLRKPQSLKDLESQLPRLELK 265
            :.:|   |..|.:....:|:  ||:...|:.:.|     ||.:..:|  ::|.|:..::....:.
Frog   245 VAMLIRKERNLTINEDKILSEMEKVFKLEREIAK-----AEASEEIR--ENLNDIYKKMTLSGIA 302

  Fly   266 RYFETIL--EGIDW----------------DSKTLLLVADLDYLQGLQ-------RLLAEHTSDP 305
            :.:...:  :.|:|                :::.:.|:.. |||:.|:       |.|..:....
Frog   303 KTYPLKMNDQNINWLKLINAIISPGGVSIEENEQVALICS-DYLKKLRFLNKYKARELQNYLGWR 366

  Fly   306 MVLSTWLLLQLP-----AYFELRLHDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDV 365
            .:||....|.|.     .:.:..|:.:...|:....|:..|...|...:|||.::..|....:.|
Frog   367 YILSAINDLSLEYKNTGIHLKKALYGNAAEGSDWQTCVTYLNDNMEDAIGRLYLKETLSADIEHV 431

  Fly   366 YDTAIQQIAVLFRDLKQQFELVLNETEVFNEDLVTRNLARDKLRAMR---LLTPRLQDPINGGPG 427
              ....::..:..::::.|..:|.|.:..:||  |:..|..|:.::.   ..:..:.|......|
Frog   432 --KVKDKVKEIIAEIRRAFLEMLEEMDWMDED--TKKRAARKVASINERIAFSEDIMDDFKLNEG 492

  Fly   428 TPQLGGNCDANLLQLSLSQAKLEYRQVFGEPVTS-----------VPADPLSVNAYYRLKLNRIE 481
            ..:|....|      .|.:.|.:|.:...:.:||           ||. |..|||:|.|..|.|.
Frog   493 YSELEFRVD------ELFENKQKYIEFVQKKMTSRLRKQVNKNEWVPG-PAHVNAFYSLTYNEIV 550

  Fly   482 LPLGLMATPLIQQQCSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAII 546
            .|.|::.||..     ..:...|....|:|.|:.||:.|.||..|.|:|..|.|.| .|:..:::
Frog   551 FPAGILQTPFF-----SSSQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVN-WWTNASMM 609

  Fly   547 RFGLRAGCYL-----------GVRYSNATLTVNENIADTEGLRLALDTYR-----HRS------- 588
            .|...:.|::           |.:|.|...|:.|||:|..|:|.|...::     |:.
Frog   610 NFSNLSQCFVNQYGNYSWDEAGGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSHKEDDLLPGI 674

  Fly   589 GATNLRTFFVAFAQNWCG----TVASTSGLSQHAGHAERVNNVVG---NMPEFGDTFECKATSQM 646
            ...:.:.||::|.|.|||    ..|:|  |.:...|...:..|:|   |.|||...|.|...:.|
Frog   675 DLDSDQLFFISFGQIWCGMHRPEYAAT--LIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAYM 737

  Fly   647 NPVNKCHIW 655
            ||..||.:|
Frog   738 NPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	163/743 (22%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	159/728 (22%)
mme	XP_031758820.1	M13	71..744	CDD:341056	159/727 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020